Biomaterial Database

Development of germinal centres in the spleen in infants related to birth and unexpected death. 1976

A J Al Barzanji, and S R Penny, and J L Emery

The development of germinal centres in the spleen has been estimated in a series of 266 children dying in hospital and 205 children presenting as unexpected death in infancy. The prevalence of germinal centres in the spleen increases rapidly after birth. The percentage of Malpighian bodies showing germinal centres in the spleen is greater in all categories of our classification of death in children dying unexpectedly at home when these are compared with hospital deaths. It is concluded that the children presenting as unexpected death in infancy show no evidence of any deficiency in cellular immunological response and may well have been subjected to increased or precocious antigenic stimulation.

UI	MeSH Term	Description	Entries
D007111	Immunity, Cellular	Manifestations of the immune response which are mediated by antigen-sensitized T-lymphocytes via lymphokines or direct cytotoxicity. This takes place in the absence of circulating antibody or where antibody plays a subordinate role.	Cell-Mediated Immunity,Cellular Immune Response,Cell Mediated Immunity,Cell-Mediated Immunities,Cellular Immune Responses,Cellular Immunities,Cellular Immunity,Immune Response, Cellular,Immune Responses, Cellular,Immunities, Cell-Mediated,Immunities, Cellular,Immunity, Cell-Mediated,Response, Cellular Immune
D007223	Infant	A child between 1 and 23 months of age.	Infants
D007231	Infant, Newborn	An infant during the first 28 days after birth.	Neonate,Newborns,Infants, Newborn,Neonates,Newborn,Newborn Infant,Newborn Infants
D008214	Lymphocytes	White blood cells formed in the body's lymphoid tissue. The nucleus is round or ovoid with coarse, irregularly clumped chromatin while the cytoplasm is typically pale blue with azurophilic (if any) granules. Most lymphocytes can be classified as either T or B (with subpopulations of each), or NATURAL KILLER CELLS.	Lymphoid Cells,Cell, Lymphoid,Cells, Lymphoid,Lymphocyte,Lymphoid Cell
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000367	Age Factors	Age as a constituent element or influence contributing to the production of a result. It may be applicable to the cause or the effect of a circumstance. It is used with human or animal concepts but should be differentiated from AGING, a physiological process, and TIME FACTORS which refers only to the passage of time.	Age Reporting,Age Factor,Factor, Age,Factors, Age
D013154	Spleen	An encapsulated lymphatic organ through which venous blood filters.
D013398	Sudden Infant Death	The abrupt and unexplained death of an apparently healthy infant under one year of age, remaining unexplained after a thorough case investigation, including performance of a complete autopsy, examination of the death scene, and review of the clinical history. (Pediatr Pathol 1991 Sep-Oct;11(5):677-84)	Cot Death,Crib Death,SIDS,Death, Sudden Infant,SID,Sudden Infant Death Syndrome,Cot Deaths,Death, Cot,Death, Crib,Infant Death, Sudden