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Debrisoquine 4-hydroxylase (CYP2D6) is a cytochrome P450 enzyme involved in the metabolism of most neuroleptics, which are the drugs of choice for the treatment of psychotic symptoms. CYP2D6 in the brain was suggested to be functionally similar to the dopamine transporter, thus possibly influencing a neurotransmitter system involved in schizophrenia. Swedish schizophrenic patients (n = 124) and control individuals (n = 85) were investigated for two CYP2D6 polymorphisms, responsible for approximately 90% of mutations leading to poor debrisoquine metabolism. No significant CYP2D6 allele or genotype difference was found between schizophrenic patients and control individuals. Taken together with previous results, no major effect appears to be caused by the CYP2D6 gene on schizophrenia.
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
January 1994,
Psychiatric genetics,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
April 1996,
American journal of medical genetics,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
February 1995,
American journal of medical genetics,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
September 2001,
Psychiatric genetics,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
January 2003,
Journal of neurology, neurosurgery, and psychiatry,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
October 2002,
Acta neuropsychiatrica,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
December 1998,
Cancer epidemiology, biomarkers & prevention : a publication of the American Association for Cancer Research, cosponsored by the American Society of Preventive Oncology,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
May 1995,
Movement disorders : official journal of the Movement Disorder Society,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
July 1998,
Schizophrenia research,
E G Jönsson, and
M L Dahl, and
H K Roh, and
M Jerling, and
G C Sedvall
November 1999,
Schizophrenia research,
