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In order to investigate whether soluble intercellular adhesion molecule-1 (sICAM-1) and soluble interleukin-2 receptors (sIL-2R) were present in scleroderma skin, and to compare their levels to concentrations measured in plasma and clinical parameters, we examined suction blister fluid and plasma from 13 patients with systemic sclerosis and 11 healthy volunteers. Suction blisters and biopsies were from the transition zone between normal skin and scleroderma, and uninvolved abdominal skin. The levels of sICAM-1 and sIL-2R were significantly increased in both plasma and suction blister fluid from systemic sclerosis patients compared with healthy volunteers. ICAM-1 was localized to vessels and perivascular mononuclear infiltrates by immunohistochemical methods. IL-2R was expressed by CD3-positive cells. The elevated levels of sICAM-1 and sIL-2R in suction blister fluid point towards activation of endothelial cells and T cells in both the transition zone and uninvolved skin of systemic sclerosis patients.
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
January 2004,
European cytokine network,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
August 1993,
Cancer letters,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
October 1994,
Journal of dermatological science,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
January 1994,
Acta microbiologica et immunologica Hungarica,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
September 1996,
Acta dermato-venereologica,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
January 1996,
Allergologia et immunopathologia,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
December 1996,
Clinical and experimental immunology,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
September 1994,
Digestive diseases and sciences,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
January 1996,
Clinical rheumatology,
K Søndergaard, and
K Stengaard-Pedersen, and
H Zachariae, and
L Heickendorff, and
M Deleuran, and
B Deleuran
January 1996,
Rivista europea per le scienze mediche e farmacologiche = European review for medical and pharmacological sciences = Revue europeenne pour les sciences medicales et pharmacologiques,
