-transparent.png){kind=logo}
Four pyrrolo[1,2-d][1,2,4]triazines and four thiazolo[3,4-d][1,2,4]triazines were synthesized from trans-4-hydroxy-L-proline and L-thiaproline, respectively. The synthetic route involved formation of hydrazides followed by cyclization with orthoesters. The proliferative response to human lymphocyte mitogen (phytohemagglutinin) revealed significant immunostimulant activity for all test drugs. Furthermore, some triazine derivatives were effective to activate production of free oxygen radical by phagocytes in response to stimulation by opsonized zymosan.
Related Publications
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
January 1996,
Archiv der Pharmazie,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
November 1985,
Journal of medicinal chemistry,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
May 2010,
Molecules (Basel, Switzerland),
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
November 1989,
Journal of medicinal chemistry,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
January 1988,
Annals of the New York Academy of Sciences,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
April 2008,
Bioorganic & medicinal chemistry letters,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
May 2017,
Archiv der Pharmazie,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
November 1986,
Die Pharmazie,
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
March 2020,
Molecules (Basel, Switzerland),
V Issartel, and
V Spehner, and
P Coudert, and
E Seilles, and
J Couquelet
August 2011,
Organic letters,
