Biomaterial Database

The 18th C.L. Oakley Lecture. Pathogenicity of enteropathogenic Escherichia coli. 1998

T J Baldwin

Institute of Infections and Immunity, School of Clinical Laboratory Sciences, University Hospital, Queen's Medical Centre, Nottingham.

Enteropathogenic Escherichia coli (EPEC) remain an important world-wide cause of diarrhoeal disease and mortality of infants and young children. Research programmes around the world have, in recent times, made enormous strides towards a better understanding of EPEC pathogenesis, yielding unique insights into the molecular intercourse between host and pathogen. Recombinant DNA and cell biology techniques have provided powerful tools, giving the first intriguing glimpses of a wealth of bacterial products mediating complex host:pathogen interactions involving the subversion of normal host signalling processes. Much has been discovered since 1945, when E. coli was first implicated as a cause of diarrhoea. However, many questions remain unanswered and many more remain unasked. Much remains to be discovered, especially in the area of molecular interactions between host and pathogen and how they relate to the manifestation of disease in the patient.

UI	MeSH Term	Description	Entries
D007223	Infant	A child between 1 and 23 months of age.	Infants
D002675	Child, Preschool	A child between the ages of 2 and 5.	Children, Preschool,Preschool Child,Preschool Children
D003967	Diarrhea	An increased liquidity or decreased consistency of FECES, such as running stool. Fecal consistency is related to the ratio of water-holding capacity of insoluble solids to total water, rather than the amount of water present. Diarrhea is not hyperdefecation or increased fecal weight.	Diarrheas
D004926	Escherichia coli	A species of gram-negative, facultatively anaerobic, rod-shaped bacteria (GRAM-NEGATIVE FACULTATIVELY ANAEROBIC RODS) commonly found in the lower part of the intestine of warm-blooded animals. It is usually nonpathogenic, but some strains are known to produce DIARRHEA and pyogenic infections. Pathogenic strains (virotypes) are classified by their specific pathogenic mechanisms such as toxins (ENTEROTOXIGENIC ESCHERICHIA COLI), etc.	Alkalescens-Dispar Group,Bacillus coli,Bacterium coli,Bacterium coli commune,Diffusely Adherent Escherichia coli,E coli,EAggEC,Enteroaggregative Escherichia coli,Enterococcus coli,Diffusely Adherent E. coli,Enteroaggregative E. coli,Enteroinvasive E. coli,Enteroinvasive Escherichia coli
D004927	Escherichia coli Infections	Infections with bacteria of the species ESCHERICHIA COLI.	E coli Infections,E. coli Infection,Infections, E coli,Infections, Escherichia coli,E coli Infection,E. coli Infections,Escherichia coli Infection,Infection, E coli,Infection, E. coli,Infection, Escherichia coli
D006113	United Kingdom	Country in northwestern Europe including Great Britain and the northern one-sixth of the island of Ireland, located between the North Sea and north Atlantic Ocean. The capital is London.	Great Britain,Isle of Man
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D014774	Virulence	The degree of pathogenicity within a group or species of microorganisms or viruses as indicated by case fatality rates and/or the ability of the organism to invade the tissues of the host. The pathogenic capacity of an organism is determined by its VIRULENCE FACTORS.	Pathogenicity
D049670	History, 17th Century	Time period from 1601 through 1700 of the common era.	17th Century History,17th Cent. History (Medicine),17th Cent. History of Medicine,17th Cent. Medicine,Historical Events, 17th Century,History of Medicine, 17th Cent.,History, Seventeenth Century,Medical History, 17th Cent.,Medicine, 17th Cent.,17th Cent. Histories (Medicine),17th Century Histories,Cent. Histories, 17th (Medicine),Century Histories, Seventeenth,Century History, 17th,Century History, Seventeenth,Histories, 17th Cent. (Medicine),Histories, 17th Century,Histories, Seventeenth Century,History, 17th Cent. (Medicine),Seventeenth Century Histories,Seventeenth Century History
D049671	History, 18th Century	Time period from 1701 through 1800 of the common era.	18th Century History,18th Cent. History (Medicine),18th Cent. History of Medicine,18th Cent. Medicine,Historical Events, 18th Century,History of Medicine, 18th Cent.,History, Eighteenth Century,Medical History, 18th Cent.,Medicine, 18th Cent.,18th Century Histories,Cent. History, 18th (Medicine),Cent. Medicine, 18th,Century Histories, 18th,Century Histories, Eighteenth,Century History, 18th,Century History, Eighteenth,Eighteenth Century Histories,Eighteenth Century History,Histories, 18th Century,Histories, Eighteenth Century,History, 18th Cent. (Medicine)