Biomaterial Database

[Polymorphism of group specific component (Gc) in nine Han subpopulations in China]. 1997

J Xu, and Q Tan, and R Du

Institute of Genetics, Chinese Academy of Sciences, Beijing.

Isoelectric focusing (IEF) followed by immunofixation in thin layer polyacrylamide gels (pH4-6) was used to analyse the Gc subtypes of 1841 individuals from nine Han geographically distributed populations in China. The Gc1F gene frequencies in these Han subpopulations from Lanzhou, Huhhot, Harbin, Xi'an, Zhengzhou, Chengdu, Guiyang, Zhangzhou and Harras in Guangdong Province were 0.3905, 0.4333, 0.4193, 0.4146, 0.4182, 0.4035, 0.4045, 0.4381 and 0.4347 respectively; Gc1S were 0.3071, 0.2190, 0.2734, 0.2261, 0.2182, 0.2871, 0.2889, 0.2738 and 0.2764 respectively; Gc2 were 0.2786, 0.3357, 0.2917, 0.3367, 0.3295, 0.2896, 0.3065, 0.2667, and 0.2814 respectively. GcV were 0.0238, 0.0119, 0.0156, 0.0226, 0.0341, 0.0198, 0.0000, 0.0214 and 0.0075 respectively. The results of present study indicated a clear cline of linear change from north to south China in allelic frequency at the Group-Specific Component (Gc) locus among nine Chinese populations. Three alleles, Gc1F, Gc2 and GcV, showed frequencies varying from 0.3905 to 0.4381, from 0.2786 to 0.3367 and from nil to 0.0341, respectively, over these geographical subpopulations. In addition, some rare variant phenotypes of Gc in Chinese populations were discussed.

UI	MeSH Term	Description	Entries
D007525	Isoelectric Focusing	Electrophoresis in which a pH gradient is established in a gel medium and proteins migrate until they reach the site (or focus) at which the pH is equal to their isoelectric point.	Electrofocusing,Focusing, Isoelectric
D011110	Polymorphism, Genetic	The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level.	Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D002681	China	A country spanning from central Asia to the Pacific Ocean.	Inner Mongolia,Manchuria,People's Republic of China,Sinkiang,Mainland China
D005787	Gene Frequency	The proportion of one particular in the total of all ALLELES for one genetic locus in a breeding POPULATION.	Allele Frequency,Genetic Equilibrium,Equilibrium, Genetic,Allele Frequencies,Frequencies, Allele,Frequencies, Gene,Frequency, Allele,Frequency, Gene,Gene Frequencies
D014809	Vitamin D-Binding Protein	An alpha-globulin found in the plasma of man and other vertebrates. It is apparently synthesized in the liver and carries vitamin D and its metabolites through the circulation and mediates the response of tissue. It is also known as group-specific component (Gc). Gc subtypes are used to determine specific phenotypes and gene frequencies. These data are employed in the classification of population groups, paternity investigations, and in forensic medicine.	Group-Specific Component Globulin,Vitamin D-Binding Globulin,25-HCC-Binding Protein,25-Hydroxycholecalciferol-Binding Protein,25-Hydroxyvitamin D-Binding Protein,Calciferol-Binding Protein,Gc Globulin,Transcalciferin,25 HCC Binding Protein,25 Hydroxycholecalciferol Binding Protein,25 Hydroxyvitamin D Binding Protein,Calciferol Binding Protein,Component Globulin, Group-Specific,Globulin, Gc,Globulin, Group-Specific Component,Globulin, Vitamin D-Binding,Group Specific Component Globulin,Vitamin D Binding Globulin,Vitamin D Binding Protein