Biomaterial Database

Is mts1(S100A4) gene involved in the metastatic process modulated by gamma-interferon? 1998

R Chiaramonte, and S Fasola, and P L Lollini, and C De Giovanni, and P Comi

Dipartimento di Scienze e Tecnologie Biomediche, LITA, Università degli Studi di Milano, Italia.

This study investigates the involvement of mts1 (S100A4) in the metastatic process. We have evaluated the levels of mts1 gene in murine cancer cells following modulation of the metastatic ability. We report here that modulation of the expression of mts1 gene in cells derived from a breast murine adenocarcinoma (TS/A) did not correlate with metastatic ability either when pretreated in vitro with gamma-interferon (gamma-IFN) or following transfection with gamma-IFN gene. In another series of experiments we treated the cell lines B16-A and B78H1, both derived from B16 melanoma, with gamma-IFN. An increased expression of mts1 was found only in B16-A, but not B78H 1, correlated with a strong increase in metastatic activity of B16-A clone upon gamma-IFN treatment.

UI	MeSH Term	Description	Entries
D007371	Interferon-gamma	The major interferon produced by mitogenically or antigenically stimulated LYMPHOCYTES. It is structurally different from TYPE I INTERFERON and its major activity is immunoregulation. It has been implicated in the expression of CLASS II HISTOCOMPATIBILITY ANTIGENS in cells that do not normally produce them, leading to AUTOIMMUNE DISEASES.	Interferon Type II,Interferon, Immune,gamma-Interferon,Interferon, gamma,Type II Interferon,Immune Interferon,Interferon, Type II
D008546	Melanoma, Experimental	Experimentally induced tumor that produces MELANIN in animals to provide a model for studying human MELANOMA.	B16 Melanoma,Melanoma, B16,Melanoma, Cloudman S91,Melanoma, Harding-Passey,Experimental Melanoma,Experimental Melanomas,Harding Passey Melanoma,Melanomas, Experimental,B16 Melanomas,Cloudman S91 Melanoma,Harding-Passey Melanoma,Melanoma, Harding Passey,Melanomas, B16,S91 Melanoma, Cloudman
D009362	Neoplasm Metastasis	The transfer of a neoplasm from one organ or part of the body to another remote from the primary site.	Metastase,Metastasis,Metastases, Neoplasm,Metastasis, Neoplasm,Neoplasm Metastases,Metastases
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D014407	Tumor Cells, Cultured	Cells grown in vitro from neoplastic tissue. If they can be established as a TUMOR CELL LINE, they can be propagated in cell culture indefinitely.	Cultured Tumor Cells,Neoplastic Cells, Cultured,Cultured Neoplastic Cells,Cell, Cultured Neoplastic,Cell, Cultured Tumor,Cells, Cultured Neoplastic,Cells, Cultured Tumor,Cultured Neoplastic Cell,Cultured Tumor Cell,Neoplastic Cell, Cultured,Tumor Cell, Cultured
D015152	Blotting, Northern	Detection of RNA that has been electrophoretically separated and immobilized by blotting on nitrocellulose or other type of paper or nylon membrane followed by hybridization with labeled NUCLEIC ACID PROBES.	Northern Blotting,Blot, Northern,Northern Blot,Blots, Northern,Blottings, Northern,Northern Blots,Northern Blottings
D015674	Mammary Neoplasms, Animal	Tumors or cancer of the MAMMARY GLAND in animals (MAMMARY GLANDS, ANIMAL).	Animal Mammary Carcinoma,Mammary Carcinoma, Animal,Mammary Neoplasms,Neoplasms, Mammary,Animal Mammary Carcinomas,Animal Mammary Neoplasm,Animal Mammary Neoplasms,Carcinoma, Animal Mammary,Carcinomas, Animal Mammary,Mammary Carcinomas, Animal,Mammary Neoplasm,Mammary Neoplasm, Animal,Neoplasm, Animal Mammary,Neoplasm, Mammary,Neoplasms, Animal Mammary
D051379	Mice	The common name for the genus Mus.	Mice, House,Mus,Mus musculus,Mice, Laboratory,Mouse,Mouse, House,Mouse, Laboratory,Mouse, Swiss,Mus domesticus,Mus musculus domesticus,Swiss Mice,House Mice,House Mouse,Laboratory Mice,Laboratory Mouse,Mice, Swiss,Swiss Mouse,domesticus, Mus musculus
D019942	Genes, p16	Tumor suppressor genes located on human chromosome 9 in the region 9p21. This gene is either deleted or mutated in a wide range of malignancies. (From Segen, Current Med Talk, 1995) Two alternatively spliced gene products are encoded by p16: CYCLIN-DEPENDENT KINASE INHIBITOR P16 and TUMOR SUPPRESSOR PROTEIN P14ARF.	CDKN2 Genes,Genes, CDKN2,Genes, MTS1,Genes, p16INK4,MTS1 Genes,p16 Genes,p16INK4 Genes,Genes, CDKN2A,Genes, p16INK4A,CDKN2 Gene,CDKN2A Gene,CDKN2A Genes,MTS1 Gene,p16 Gene,p16INK4 Gene,p16INK4A Gene,p16INK4A Genes