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Interleukin-8 (IL-8) is a cytokine, which possesses both chemotactic and activating properties for neutrophils, lymphocytes and basophils. Various evidence has indicated IL-8 to be implicated in the pathophysiology of immune-mediated renal diseases. We thus examined the expression of IL-8 in renal diseases. We detected the expression of IL-8 both in mRNA and the protein levels in renal biopsy specimens obtained from patients with IgA nephropathy and lupus nephritis. A significant correlation was found between the expression of IL-8 mRNA and the number of neutrophils in the glomerulus. We also found a negative correlation between the expression of IL-8 mRNA and creatinine clearance. Our study thus suggested IL-8 to be involved in the pathophysiology of proliferative glomerulonephritis.
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
November 1997,
Otolaryngology--head and neck surgery : official journal of American Academy of Otolaryngology-Head and Neck Surgery,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
March 2001,
American journal of obstetrics and gynecology,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
September 2000,
The Journal of urology,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
May 2004,
JOP : Journal of the pancreas,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
June 2004,
American journal of kidney diseases : the official journal of the National Kidney Foundation,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
March 2005,
The Journal of physiology,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
August 1999,
Oral surgery, oral medicine, oral pathology, oral radiology, and endodontics,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
October 1991,
The Journal of biological chemistry,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
September 2000,
Gut,
T Sekikawa, and
N Kashihara, and
K Maruyama, and
M Satoh, and
K Okamoto, and
K Kanao, and
Y Maeshima, and
H Sugiyama, and
Y Yamasaki, and
H Makino
August 1995,
Molecular immunology,
