Biomaterial Database

[Angiotensin-converting enzyme inhibitors. Familiar drugs--new indications]. 1998

P Gregor

Kardiocentrum FN KV a II. interní klinika 3. LF UK, Praha.

Angiotensin converting enzyme inhibitors (ACE) have become an important part in the pharmacotherapy of hypertension, in this indication they were used for the first time in the eighties. Later the indication was extended to heart failure (where they evidently reduce the mortality), acute myocardial infarction (there they prevent cardiac remodelling), and in myocarditis (vasodilatation, effect on spasms and on free oxygen radicals). As to non-cardiological indications the most important indications are nephrological-diabetic and non-diabetic nephropathies. Nowadays already different types of ACE inhibitors are available. They differ as to their chemical structure (they contain a sulphydryl or carboxyl group in the molecule, they are proline derivatives etc.) as well as by other properties (lipophilia, specificity, absorption rate, period of action). The authors gives a list of preparations encountered most frequently on our market and they discuss non obvious indications.

UI	MeSH Term	Description	Entries
D007674	Kidney Diseases	Pathological processes of the KIDNEY or its component tissues.	Disease, Kidney,Diseases, Kidney,Kidney Disease
D006331	Heart Diseases	Pathological conditions involving the HEART including its structural and functional abnormalities.	Cardiac Disorders,Heart Disorders,Cardiac Diseases,Cardiac Disease,Cardiac Disorder,Heart Disease,Heart Disorder
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000806	Angiotensin-Converting Enzyme Inhibitors	A class of drugs whose main indications are the treatment of hypertension and heart failure. They exert their hemodynamic effect mainly by inhibiting the renin-angiotensin system. They also modulate sympathetic nervous system activity and increase prostaglandin synthesis. They cause mainly vasodilation and mild natriuresis without affecting heart rate and contractility.	ACE Inhibitor,ACE Inhibitors,Angiotensin Converting Enzyme Inhibitor,Angiotensin I-Converting Enzyme Inhibitor,Angiotensin-Converting Enzyme Inhibitor,Kininase II Inhibitor,Kininase II Inhibitors,Angiotensin I-Converting Enzyme Inhibitors,Angiotensin-Converting Enzyme Antagonists,Antagonists, Angiotensin-Converting Enzyme,Antagonists, Kininase II,Inhibitors, ACE,Inhibitors, Angiotensin-Converting Enzyme,Inhibitors, Kininase II,Kininase II Antagonists,Angiotensin Converting Enzyme Antagonists,Angiotensin Converting Enzyme Inhibitors,Angiotensin I Converting Enzyme Inhibitor,Angiotensin I Converting Enzyme Inhibitors,Antagonists, Angiotensin Converting Enzyme,Enzyme Antagonists, Angiotensin-Converting,Enzyme Inhibitor, Angiotensin-Converting,Enzyme Inhibitors, Angiotensin-Converting,II Inhibitor, Kininase,Inhibitor, ACE,Inhibitor, Angiotensin-Converting Enzyme,Inhibitor, Kininase II,Inhibitors, Angiotensin Converting Enzyme