Passive immunization of newborn rhesus macaques prevents oral simian immunodeficiency virus infection. 1998

K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
California Regional Primate Research Center, Department of Pathology, Microbiology, and Immunology, School of Veterinary Medicine, University of California, Davis 95616-8542, USA.

To determine if passively acquired antiviral antibodies modulate virus transmission and disease progression in human pediatric AIDS, the potential of pre- and postexposure passive immunization with hyperimmune serum to prevent oral simian immunodeficiency virus (SIV) infection or disease progression in newborn rhesus macaques was tested. Untreated neonates became infected after oral SIV inoculation and had high viremia, and most animals developed fatal AIDS within 3 months. In contrast, SIV hyperimmune serum given subcutaneously prior to oral SIV inoculation protected 6 newborns against infection. When this SIV hyperimmune serum was given to 3 newborns 3 weeks after oral SIV inoculation, viremia was not reduced, and all 3 infants died within 3 months of age due to AIDS and immune-complex disease. These results suggest that passively acquired antihuman immunodeficiency virus (HIV) IgG may decrease perinatal HIV transmission. However, anti-HIV IgG may not impart therapeutic benefit to infants with established HIV infection.

UI MeSH Term Description Entries
D007070 Immunoglobulin A Represents 15-20% of the human serum immunoglobulins, mostly as the 4-chain polymer in humans or dimer in other mammals. Secretory IgA (IMMUNOGLOBULIN A, SECRETORY) is the main immunoglobulin in secretions. IgA,IgA Antibody,IgA1,IgA2,Antibody, IgA
D007074 Immunoglobulin G The major immunoglobulin isotype class in normal human serum. There are several isotype subclasses of IgG, for example, IgG1, IgG2A, and IgG2B. Gamma Globulin, 7S,IgG,IgG Antibody,Allerglobuline,IgG(T),IgG1,IgG2,IgG2A,IgG2B,IgG3,IgG4,Immunoglobulin GT,Polyglobin,7S Gamma Globulin,Antibody, IgG,GT, Immunoglobulin
D007116 Immunization, Passive Transfer of immunity from immunized to non-immune host by administration of serum antibodies, or transplantation of lymphocytes (ADOPTIVE TRANSFER). Convalescent Plasma Therapy,Immunoglobulin Therapy,Immunotherapy, Passive,Normal Serum Globulin Therapy,Passive Antibody Transfer,Passive Transfer of Immunity,Serotherapy,Passive Immunotherapy,Therapy, Immunoglobulin,Antibody Transfer, Passive,Passive Immunization,Therapy, Convalescent Plasma,Transfer, Passive Antibody
D007668 Kidney Body organ that filters blood for the secretion of URINE and that regulates ion concentrations. Kidneys
D008253 Macaca mulatta A species of the genus MACACA inhabiting India, China, and other parts of Asia. The species is used extensively in biomedical research and adapts very well to living with humans. Chinese Rhesus Macaques,Macaca mulatta lasiota,Monkey, Rhesus,Rhesus Monkey,Rhesus Macaque,Chinese Rhesus Macaque,Macaca mulatta lasiotas,Macaque, Rhesus,Rhesus Macaque, Chinese,Rhesus Macaques,Rhesus Macaques, Chinese,Rhesus Monkeys
D002648 Child A person 6 to 12 years of age. An individual 2 to 5 years old is CHILD, PRESCHOOL. Children
D004797 Enzyme-Linked Immunosorbent Assay An immunoassay utilizing an antibody labeled with an enzyme marker such as horseradish peroxidase. While either the enzyme or the antibody is bound to an immunosorbent substrate, they both retain their biologic activity; the change in enzyme activity as a result of the enzyme-antibody-antigen reaction is proportional to the concentration of the antigen and can be measured spectrophotometrically or with the naked eye. Many variations of the method have been developed. ELISA,Assay, Enzyme-Linked Immunosorbent,Assays, Enzyme-Linked Immunosorbent,Enzyme Linked Immunosorbent Assay,Enzyme-Linked Immunosorbent Assays,Immunosorbent Assay, Enzyme-Linked,Immunosorbent Assays, Enzyme-Linked
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000163 Acquired Immunodeficiency Syndrome An acquired defect of cellular immunity associated with infection by the human immunodeficiency virus (HIV), a CD4-positive T-lymphocyte count under 200 cells/microliter or less than 14% of total lymphocytes, and increased susceptibility to opportunistic infections and malignant neoplasms. Clinical manifestations also include emaciation (wasting) and dementia. These elements reflect criteria for AIDS as defined by the CDC in 1993. AIDS,Immunodeficiency Syndrome, Acquired,Immunologic Deficiency Syndrome, Acquired,Acquired Immune Deficiency Syndrome,Acquired Immuno-Deficiency Syndrome,Acquired Immuno Deficiency Syndrome,Acquired Immuno-Deficiency Syndromes,Acquired Immunodeficiency Syndromes,Immuno-Deficiency Syndrome, Acquired,Immuno-Deficiency Syndromes, Acquired,Immunodeficiency Syndromes, Acquired,Syndrome, Acquired Immuno-Deficiency,Syndrome, Acquired Immunodeficiency,Syndromes, Acquired Immuno-Deficiency,Syndromes, Acquired Immunodeficiency
D000284 Administration, Oral The giving of drugs, chemicals, or other substances by mouth. Drug Administration, Oral,Administration, Oral Drug,Oral Administration,Oral Drug Administration,Administrations, Oral,Administrations, Oral Drug,Drug Administrations, Oral,Oral Administrations,Oral Drug Administrations

Related Publications

K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
January 2003, Journal of virology,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
November 1990, AIDS research and human retroviruses,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
September 2010, Journal of proteome research,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
August 2000, Journal of medical primatology,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
August 2001, The Journal of infectious diseases,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
November 2015, Journal of neuropathology and experimental neurology,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
December 2019, mBio,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
October 2020, Journal of virology,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
August 1990, Journal of virology,
K K Van Rompay, and C J Berardi, and S Dillard-Telm, and R P Tarara, and D R Canfield, and C R Valverde, and D C Montefiori, and K S Cole, and R C Montelaro, and C J Miller, and M L Marthas
June 2002, Journal of medical primatology,
Copied contents to your clipboard!