Biomaterial Database

Inhibition of the fast Na+ current by taurine in guinea pig ventricular myocytes. 1998

H Satoh

Department of Pharmacology, Nara Medical University, Japan.

1. Effects of taurine on the fast Na+ current (INa) in isolated guinea pig ventricular cardiomyocytes were examined by using the whole-cell voltage-clamp method. Experiments were performed at room temperature (22 degrees C). 2. Test pulses were applied from -60 to +40 mV from a holding potential of -90 mV. Addition of taurine to the bath solution markedly inhibited the INa in a concentration-dependent manner; at -30 mV, by 39.0 +/- 4.1% (n = 8, P < 0.01) at 10 mM and by 56.1 +/- 4.7% (n = 9, P < 0.001) at 20 mM. 3. Simultaneously, the time constant of inactivation phase for INa decreased to 0.95 +/- 0.4 ms (n = 8, P < 0.05) at 10 mM and to 1.02 +/- 0.3 ms (n = 9, P < 0.05) at 20 mM, from 1.29 +/- 0.3 ms in normal Tyrode solution. 4. These results indicate that taurine inhibits the INa current, which would play an important role in the cell functions.

UI	MeSH Term	Description	Entries
D006168	Guinea Pigs	A common name used for the genus Cavia. The most common species is Cavia porcellus which is the domesticated guinea pig used for pets and biomedical research.	Cavia,Cavia porcellus,Guinea Pig,Pig, Guinea,Pigs, Guinea
D006352	Heart Ventricles	The lower right and left chambers of the heart. The right ventricle pumps venous BLOOD into the LUNGS and the left ventricle pumps oxygenated blood into the systemic arterial circulation.	Cardiac Ventricle,Cardiac Ventricles,Heart Ventricle,Left Ventricle,Right Ventricle,Left Ventricles,Right Ventricles,Ventricle, Cardiac,Ventricle, Heart,Ventricle, Left,Ventricle, Right,Ventricles, Cardiac,Ventricles, Heart,Ventricles, Left,Ventricles, Right
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D013654	Taurine	A conditionally essential nutrient, important during mammalian development. It is present in milk but is isolated mostly from ox bile and strongly conjugates bile acids.	Taufon,Tauphon,Taurine Hydrochloride,Taurine Zinc Salt (2:1),Taurine, Monopotassium Salt
D018408	Patch-Clamp Techniques	An electrophysiologic technique for studying cells, cell membranes, and occasionally isolated organelles. All patch-clamp methods rely on a very high-resistance seal between a micropipette and a membrane; the seal is usually attained by gentle suction. The four most common variants include on-cell patch, inside-out patch, outside-out patch, and whole-cell clamp. Patch-clamp methods are commonly used to voltage clamp, that is control the voltage across the membrane and measure current flow, but current-clamp methods, in which the current is controlled and the voltage is measured, are also used.	Patch Clamp Technique,Patch-Clamp Technic,Patch-Clamp Technique,Voltage-Clamp Technic,Voltage-Clamp Technique,Voltage-Clamp Techniques,Whole-Cell Recording,Patch-Clamp Technics,Voltage-Clamp Technics,Clamp Technique, Patch,Clamp Techniques, Patch,Patch Clamp Technic,Patch Clamp Technics,Patch Clamp Techniques,Recording, Whole-Cell,Recordings, Whole-Cell,Technic, Patch-Clamp,Technic, Voltage-Clamp,Technics, Patch-Clamp,Technics, Voltage-Clamp,Technique, Patch Clamp,Technique, Patch-Clamp,Technique, Voltage-Clamp,Techniques, Patch Clamp,Techniques, Patch-Clamp,Techniques, Voltage-Clamp,Voltage Clamp Technic,Voltage Clamp Technics,Voltage Clamp Technique,Voltage Clamp Techniques,Whole Cell Recording,Whole-Cell Recordings
D026941	Sodium Channel Blockers	A class of drugs that act by inhibition of sodium influx through cell membranes. Blockade of sodium channels slows the rate and amplitude of initial rapid depolarization, reduces cell excitability, and reduces conduction velocity.	Channel Blockers, Sodium,Sodium Channel Blocker,Sodium Channel Inhibitor,Sodium Channel Inhibitors,Blocker, Sodium Channel,Channel Blocker, Sodium,Channel Inhibitor, Sodium,Channel Inhibitors, Sodium,Inhibitor, Sodium Channel,Inhibitors, Sodium Channel