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In the isolated perfused rat heart cardiac rate and contractility are directly affected by four naturally occurring cannabis constituents, delta9-tetrahydrocannabinol, delta8-tetrahydrocannabinol, cannabinol and cannabidiol. All the drugs depressed myocardial contractility. Their effect on rate, however, was not uniform: delta8-Tetrahydrocannabinol produced cardiac arrhythmias but no other consistent change; both delta9-tetrahydrocannabinol and cannabinol caused tachycardia; but cannabidiol produced bradycardia, arrhythmias and asystole. In addition, as a consequent of the dispostion of the cannabinoids to accumulate in the isolated heart, high tissue concentrations appeared in conjunction with the direct cardiac effects.
K A Smiley, and
R Karler, and
S A Turkanis
December 1977,
Biochemical pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
January 1979,
General pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
February 1977,
Toxicology and applied pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
January 1978,
General pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
January 1978,
General pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
January 1979,
General pharmacology,
K A Smiley, and
R Karler, and
S A Turkanis
April 1992,
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K A Smiley, and
R Karler, and
S A Turkanis
May 2011,
Sultan Qaboos University medical journal,
K A Smiley, and
R Karler, and
S A Turkanis
December 1988,
Sheng li xue bao : [Acta physiologica Sinica],
K A Smiley, and
R Karler, and
S A Turkanis
March 1959,
The Journal of physiology,
