BIOMAT Database Logo BIOMAT Database Logo

A genetic and correlation analysis of liver cholesterol concentration in rat recombinant inbred strains fed a high cholesterol diet. 1998

A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Department of Laboratory Animal Science, Veterinary Faculty, Utrecht University, The Netherlands.

Liver cholesterol concentration in rats fed a high cholesterol diet, is under genetic control which is supported by significant differences observed among inbred strains. For instance, the Brown Norway (BN-Lx/Cub) rat developed a twofold higher liver cholesterol concentration than the spontaneously hypertensive rat (SHR/Ola). In the current study, we used 30 recombinant inbred (RI) strains, derived from BN-Lx and SHR progenitors, to locate quantitative trait loci (QTL) that are responsible for differences in liver cholesterol concentrations between the BN-Lx and SHR strains. The heritability of liver cholesterol was estimated to be 0.55 and a significant association was detected between concentration of liver cholesterol and the D10Cebrp1016s2 marker on chromosome 10 (lod score = 3.3); this putative QTL was responsible for nearly 64% of additive genetic variability and thus represents a major genetic determinant of liver cholesterol concentration. Liver cholesterol concentrations significantly correlated with intermediate density lipoprotein (IDL) cholesterol levels.

UI MeSH Term Description Entries
D008040 Genetic Linkage The co-inheritance of two or more non-allelic GENES due to their being located more or less closely on the same CHROMOSOME. Genetic Linkage Analysis,Linkage, Genetic,Analyses, Genetic Linkage,Analysis, Genetic Linkage,Genetic Linkage Analyses,Linkage Analyses, Genetic,Linkage Analysis, Genetic
D008074 Lipoproteins Lipid-protein complexes involved in the transportation and metabolism of lipids in the body. They are spherical particles consisting of a hydrophobic core of TRIGLYCERIDES and CHOLESTEROL ESTERS surrounded by a layer of hydrophilic free CHOLESTEROL; PHOSPHOLIPIDS; and APOLIPOPROTEINS. Lipoproteins are classified by their varying buoyant density and sizes. Circulating Lipoproteins,Lipoprotein,Lipoproteins, Circulating
D008099 Liver A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances. Livers
D008297 Male Males
D010641 Phenotype The outward appearance of the individual. It is the product of interactions between genes, and between the GENOTYPE and the environment. Phenotypes
D011914 Rats, Inbred BN An inbred strain of rat that is widely used in a variety of research areas such as the study of ASTHMA; CARCINOGENESIS; AGING; and LEUKEMIA. Rats, Inbred Brown Norway,Rats, BN,BN Rat,BN Rat, Inbred,BN Rats,BN Rats, Inbred,Inbred BN Rat,Inbred BN Rats,Rat, BN,Rat, Inbred BN
D011918 Rats, Inbred SHR A strain of Rattus norvegicus with elevated blood pressure used as a model for studying hypertension and stroke. Rats, Spontaneously Hypertensive,Rats, SHR,Inbred SHR Rat,Inbred SHR Rats,Rat, Inbred SHR,Rat, SHR,Rat, Spontaneously Hypertensive,SHR Rat,SHR Rat, Inbred,SHR Rats,SHR Rats, Inbred,Spontaneously Hypertensive Rat,Spontaneously Hypertensive Rats
D011995 Recombination, Genetic Production of new arrangements of DNA by various mechanisms such as assortment and segregation, CROSSING OVER; GENE CONVERSION; GENETIC TRANSFORMATION; GENETIC CONJUGATION; GENETIC TRANSDUCTION; or mixed infection of viruses. Genetic Recombination,Recombination,Genetic Recombinations,Recombinations,Recombinations, Genetic
D002352 Carrier Proteins Proteins that bind or transport specific substances in the blood, within the cell, or across cell membranes. Binding Proteins,Carrier Protein,Transport Protein,Transport Proteins,Binding Protein,Protein, Carrier,Proteins, Carrier
D002784 Cholesterol The principal sterol of all higher animals, distributed in body tissues, especially the brain and spinal cord, and in animal fats and oils. Epicholesterol

Related Publications

A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Cholesterol metabolism in serum and aorta of inbred mice fed a high-cholesterol diet.
February 1984, Japanese journal of pharmacology,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Genetic analysis of graft-versus-host disease using rat recombinant inbred strains.
May 1997, Transplantation proceedings,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Activity rhythms in inbred mice. I. Genetic analysis with recombinant inbred strains.
March 1991, Behavior genetics,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Recombinant inbred and congenic strains of the rat for genetic analysis of limb morphogenesis.
January 1996, Folia biologica,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Genetic correlation between open-field activity and defecation: analysis with the CXB recombinant-inbred strains.
September 1979, Behavior genetics,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
A genetic linkage map of the rat derived from recombinant inbred strains.
February 1996, Mammalian genome : official journal of the International Mammalian Genome Society,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Esterases in inbred strains of mice with differential cholesterolemic responses to a high-cholesterol diet.
February 1987, Atherosclerosis,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
ATR-FTIR spectroscopy reveals genomic loci regulating the tissue response in high fat diet fed BXD recombinant inbred mouse strains.
June 2013, BMC genomics,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
Genetic variability to diet-induced hippocampal dysfunction in BXD recombinant inbred (RI) mouse strains.
October 2015, Behavioural brain research,
A Bottger, and E Lankhorst, and H A van Lith, and L F van Zutphen, and V Zídek, and A Musilová, and M Simáková, and R Poledne, and V Bílá, and V Køen, and M Pravenec
The correlation between serum total cholesterol and some trace elements in serum, liver and heart of rats fed high cholesterol diet.
January 1991, Die Nahrung,
Copied contents to your clipboard!