-transparent.png){kind=logo}
The structural features and hallucinogenic properties shared by ibogaine and certain beta-carbolines prompted the evaluation of several representative beta-carbolines in rats trained with ibogaine as a discriminative stimulus. In a previous report from our laboratory harmaline completely substituted for ibogaine (83.5%). In the present study, only 6-methoxyharmalan completely substituted (86.3%). However, partial substitution was observed with harmine, harmane, harmalol, and tetrahydro-beta-carboline (THBC). Norharmane and 6,7-dimethoxy-4-ethyl-carboline-3-carboxylate (DMCM) failed to produce appreciable substitution. These results provide evidence for an ibogaine-like ether this extends to the previously reported anti-addictive effects of ibogaine remains to be established.
S Helsley, and
R A Rabin, and
J C Winter
July 1988,
The Journal of pharmacology and experimental therapeutics,
S Helsley, and
R A Rabin, and
J C Winter
June 1974,
The Journal of pharmacology and experimental therapeutics,
S Helsley, and
R A Rabin, and
J C Winter
December 1992,
Pharmacology, biochemistry, and behavior,
S Helsley, and
R A Rabin, and
J C Winter
January 1994,
Pharmacology, biochemistry, and behavior,
S Helsley, and
R A Rabin, and
J C Winter
February 1998,
Pharmacology, biochemistry, and behavior,
S Helsley, and
R A Rabin, and
J C Winter
April 2015,
Drug and alcohol dependence,
S Helsley, and
R A Rabin, and
J C Winter
July 1988,
Pharmacology, biochemistry, and behavior,
S Helsley, and
R A Rabin, and
J C Winter
January 1980,
Psychopharmacology,
S Helsley, and
R A Rabin, and
J C Winter
January 1989,
Psychopharmacology,
S Helsley, and
R A Rabin, and
J C Winter
March 1998,
Pharmacology, biochemistry, and behavior,
