Biomaterial Database

Keratoconjunctivitis sicca. 1976

J L Baum

KCS in man is often associated with a systemic disease whose pathogenesis is still obscure. A spontaneous animal model resembling Sjögren's syndrome has been developed in the NZB and NZB-NZW mouse. Other spontaneous animal models analagous to lupus erythematosis and polyarteritis have been found in dogs and Aleutian mink, respectively. Studies of the eyes and lacrimal glands in such animals, and in dogs with distemper, should be pursued. A viral etiology is implicated in each of the models. The roles of both the main and accessory lacrimal glands in normal and KCS eyes have been discussed, as well as drug-induced KCS and opportunities for its further investigation and treatment.

UI	MeSH Term	Description	Entries
D007637	Keratoconjunctivitis	Simultaneous inflammation of the cornea and conjunctiva.	Keratoconjunctivitides
D008180	Lupus Erythematosus, Systemic	A chronic, relapsing, inflammatory, and often febrile multisystemic disorder of connective tissue, characterized principally by involvement of the skin, joints, kidneys, and serosal membranes. It is of unknown etiology, but is thought to represent a failure of the regulatory mechanisms of the autoimmune system. The disease is marked by a wide range of system dysfunctions, an elevated erythrocyte sedimentation rate, and the formation of LE cells in the blood or bone marrow.	Libman-Sacks Disease,Lupus Erythematosus Disseminatus,Systemic Lupus Erythematosus,Disease, Libman-Sacks,Libman Sacks Disease
D008814	Mice, Inbred NZB	An inbred strain of mouse that is widely used as a model for AUTOIMMUNE DISEASES such as SYSTEMIC LUPUS ERYTHEMATOSUS.	Mice, NZB,Mouse, Inbred NZB,Mouse, NZB,Inbred NZB Mice,Inbred NZB Mouse,NZB Mice,NZB Mice, Inbred,NZB Mouse,NZB Mouse, Inbred
D008907	Mink	Carnivores of genera Mustela and Neovison of the family MUSTELIDAE. The European mink has white upper and lower lips while the American mink lacks white upper lip.	American Mink,European Mink,Mustela lutreola,Mustela macrodon,Mustela vison,Neovison vison,Sea Mink,Mink, American,Mink, European,Mink, Sea,Minks,Minks, Sea,Sea Minks,vison, Neovison
D010621	Phenazopyridine	A local anesthetic that has been used in urinary tract disorders. Its use is limited by problems with toxicity (primarily blood disorders) and potential carcinogenicity.	Azo-Dine,Azo-Gesic,Azo-Natural,Azo-Standard,Baridium,Geridium,Phenazo,Phenazopyridine Hydrochloride,Prodium,Pyridiate,Pyridium,Re-Azo,UTI Relief,Urogesic,Azo Dine,Azo Gesic,Azo Natural,Azo Standard,AzoDine,AzoGesic,AzoNatural,AzoStandard,Hydrochloride, Phenazopyridine,Re Azo,ReAzo
D004195	Disease Models, Animal	Naturally-occurring or experimentally-induced animal diseases with pathological processes analogous to human diseases.	Animal Disease Model,Animal Disease Models,Disease Model, Animal
D004285	Dogs	The domestic dog, Canis familiaris, comprising about 400 breeds, of the carnivore family CANIDAE. They are worldwide in distribution and live in association with people. (Walker's Mammals of the World, 5th ed, p1065)	Canis familiaris,Dog
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000453	Aleutian Mink Disease	A slow progressive disease of mink caused by the ALEUTIAN MINK DISEASE VIRUS. It is characterized by poor reproduction, weight loss, autoimmunity, hypergammaglobulinemia, increased susceptibility to bacterial infections, and death from renal failure. The disease occurs in all color types, but mink which are homozygous recessive for the Aleutian gene for light coat color are particularly susceptible.	Aleutian Disease of Mink,Disease, Aleutian Mink,Mink Disease, Aleutian
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia