Biomaterial Database

Studies of the effect of physical and chemical interactions of cellulose ethers and sulfonamides in tablets on the drug release. 1997

T Hładoń, and B Cwiertnia

Department of Inorganic and Analytical Chemistry, K. Marcinkowski University of Medical Sciences, Poznań, Poland.

The paper reports results of the studies of sulfonamide tablets obtained by the incorporation in hydrophilic carrier (Cellulose ether). The rate of sulfonamide release was determined by the paddle method. The occurrence of physical and chemical interactions of sulfonamides and cellulose ethers in the solid phase was confirmed by X-ray diffraction and thermal (TG and DSC) studies. The influence of these interactions on the sulfonamide release from the tablets was analyzed.

UI	MeSH Term	Description	Entries
D002482	Cellulose	A polysaccharide with glucose units linked as in CELLOBIOSE. It is the chief constituent of plant fibers, cotton being the purest natural form of the substance. As a raw material, it forms the basis for many derivatives used in chromatography, ion exchange materials, explosives manufacturing, and pharmaceutical preparations.	Alphacel,Avicel,Heweten,Polyanhydroglucuronic Acid,Rayophane,Sulfite Cellulose,alpha-Cellulose,Acid, Polyanhydroglucuronic,alpha Cellulose
D002626	Chemistry, Pharmaceutical	Chemistry dealing with the composition and preparation of agents having PHARMACOLOGIC ACTIONS or diagnostic use.	Medicinal Chemistry,Chemistry, Pharmaceutic,Pharmaceutic Chemistry,Pharmaceutical Chemistry,Chemistry, Medicinal
D013449	Sulfonamides	A group of compounds that contain the structure SO2NH2.	Sulfonamide,Sulfonamide Mixture,Sulfonamide Mixtures,Mixture, Sulfonamide,Mixtures, Sulfonamide
D013607	Tablets	Solid dosage forms, of varying weight, size, and shape, which may be molded or compressed, and which contain a medicinal substance in pure or diluted form. (Dorland, 28th ed)	Tablet

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