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Topographic differences in flash/pattern shift VEP data are evaluated in paranoid (n: 38), disorganized (n: 23) and residual (n: 23) schizophrenic subtypes and compared to normal controls. Increased early P1 and a restricted diffusion of the late P2 responses suggest dopaminergic over- and cholinergic underactivity in paranoid and residual schizophrenia. A distinctive pattern N145 reflects well-preserved attentional resources in the paranoid subtype. Latency increase and amplitude decrease of the pattern N145 concur with abnormal antisaccades documented in disorganized behaviour. VEP-data might help differentiate between schizophrenic subtypes.
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