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[Improvement of effectiveness of antibiotic therapy by pyrimidine derivatives in reparative regeneration of skin in rats]. 1998
A F Ismagilova, and
F S Zarudiĭ, and
D N Lazareva, and
V A Davydova, and
L T Karachurina, and
Z F Ismagilova, and
Iu G Tropynina
Institute of Organic Chemistry, Ufa Scientific Centre, Russian Academy of Sciences.
It was shown on noninbred albino rats with various affections of the skin that pyrimidine derivatives stimulated the skin reparative regeneration and increased the efficacy of antibiotic therapy of Staphylococcus and Proteus infected wounds. The therapeutic effect of 2-methyl-4-amino-6-oxypyrimidine was much higher than that of oxymethyluracil or methyluracil. The pyrimidine derivatives proved to be universal accelerators for reparative regeneration, were compatible with antibiotics and increased their efficacy.
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