Rationale is given to the proposition that aviation medicine including psychophysiology and ergonomics is a peculiar kind of aviation anthropoecology as a variety of the present-day integrative science of human. This is grounded, firstly, on analysis of any scientific finding of aviation medicine in the light of two principles of the contemporary occupational medicine, i.e. human health and reasonable risk (which is an equivalent of safety) and, secondly, systemic study from this angle of all, from molecular to social, levels of the biological integration man of flying.