Biomaterial Database

Trans isomers of long-chain n-3 polyunsaturated fatty acids in tissue lipid classes of rats fed with heated linseed oil. 1998

A Grandgirard, and A Piconneaux, and J L Sebedio, and F Julliard

Unité de nutrition lipidique, Inra, Dijon, France.

The isomerization of linolenic acid into mono- and di-trans isomers takes place during heat treatment. One of these compounds, 18:3 delta 9c, 12c, 15t can be desaturated and elongated to form, in particular, the trans isomers of eicosapentaenoic and docosahexaenoic acids. This study was undertaken to observe the incorporation of these trans long-chain n-3 polyunsaturated fatty acids into the lipid classes of several tissues. Rats were fed for 8 weeks with heated linseed oil containing high levels of trans linolenic acid isomers. The lipid classes of the liver, kidney, heart and adrenals of these rats contained various levels of these compounds. The 20:5 delta 5c, 8c, 11c, 14c, 17t represented between 80 and 90% of the total 20:5 in the phospholipids, but 22:5 delta 7c, 10c, 13c, 16c, 19t and mainly 22:6 delta 4c, 7c, 10c, 13c, 16c, 19t were only present in small quantities. This may indicate that the cis fatty acids are better metabolized in these cases. Among the tissues studied, it was interesting to note a high level of 22:5 delta 19t in the adrenals, particularly in cholesterol esters.

UI	MeSH Term	Description	Entries
D007668	Kidney	Body organ that filters blood for the secretion of URINE and that regulates ion concentrations.	Kidneys
D008043	Linseed Oil	The fixed oil obtained from the dried ripe seed of linseed, Linum usitatissimum (L. Linaceae). It is used as an emollient in liniments, pastes, and medicinal soaps, and in veterinary medicine as a laxative. It is also called flaxseed oil. (Dorland, 28th ed)	Flaxseed Oil,Oil, Flaxseed,Oil, Linseed
D008055	Lipids	A generic term for fats and lipoids, the alcohol-ether-soluble constituents of protoplasm, which are insoluble in water. They comprise the fats, fatty oils, essential oils, waxes, phospholipids, glycolipids, sulfolipids, aminolipids, chromolipids (lipochromes), and fatty acids. (Grant & Hackh's Chemical Dictionary, 5th ed)	Lipid
D008099	Liver	A large lobed glandular organ in the abdomen of vertebrates that is responsible for detoxification, metabolism, synthesis and storage of various substances.	Livers
D009206	Myocardium	The muscle tissue of the HEART. It is composed of striated, involuntary muscle cells (MYOCYTES, CARDIAC) connected to form the contractile pump to generate blood flow.	Muscle, Cardiac,Muscle, Heart,Cardiac Muscle,Myocardia,Cardiac Muscles,Heart Muscle,Heart Muscles,Muscles, Cardiac,Muscles, Heart
D010743	Phospholipids	Lipids containing one or more phosphate groups, particularly those derived from either glycerol (phosphoglycerides see GLYCEROPHOSPHOLIPIDS) or sphingosine (SPHINGOLIPIDS). They are polar lipids that are of great importance for the structure and function of cell membranes and are the most abundant of membrane lipids, although not stored in large amounts in the system.	Phosphatides,Phospholipid
D004042	Dietary Fats, Unsaturated	Unsaturated fats or oils used in foods or as a food.	Dietary Oils,Unsaturated Dietary Fats,Dietary Fat, Unsaturated,Dietary Oil,Fat, Unsaturated Dietary,Fats, Unsaturated Dietary,Oil, Dietary,Oils, Dietary,Unsaturated Dietary Fat
D006358	Hot Temperature	Presence of warmth or heat or a temperature notably higher than an accustomed norm.	Heat,Hot Temperatures,Temperature, Hot,Temperatures, Hot
D000311	Adrenal Glands	A pair of glands located at the cranial pole of each of the two KIDNEYS. Each adrenal gland is composed of two distinct endocrine tissues with separate embryonic origins, the ADRENAL CORTEX producing STEROIDS and the ADRENAL MEDULLA producing NEUROTRANSMITTERS.	Adrenal Gland,Gland, Adrenal,Glands, Adrenal
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia