BIOMAT Database Logo BIOMAT Database Logo

Vaccination with a Haemophilus influenzae type b conjugate vaccine reduces oropharyngeal carriage of H. influenzae type b among Gambian children. 1998

R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Medical Research Council Laboratories, Fajara, Banjul, The Gambia. radegbola@mrc.enda.sn

The effect of a Haemophilus influenzae type b (Hib) polyribosylribitol phosphate-tetanus toxoid conjugate vaccine (Hib/PRP-T) on oropharyngeal carriage of Hib was studied during an efficacy trial in Gambian infants. Children were vaccinated with Hib/PRP-T and diphtheria-tetanus toxoids-pertussis (DTP) or DTP alone at ages 2, 3, and 4 months. Groups of 1000 children aged 1-2 years were studied each year for 4 years. Hib was detected by production of a halo on antiserum agar plates. Carriage was significantly lower among children fully vaccinated with Hib/PRP-T given with DTP (4.4%; 95% confidence interval [CI], 3.8%-5.7%) than among children fully vaccinated with DTP alone (11.0%; 95% CI, 8.9%-13.0%) (protective effect adjusted by year = 60%; 95% CI, 44%-72%; P < .001). Hib carriage varied by year among nonvaccinated children. Hib conjugate vaccines are likely to produce a herd protective effect in underdeveloped communities, as recorded in Europe and the United States.

UI MeSH Term Description Entries
D007223 Infant A child between 1 and 23 months of age. Infants
D008297 Male Males
D008826 Microbial Sensitivity Tests Any tests that demonstrate the relative efficacy of different chemotherapeutic agents against specific microorganisms (i.e., bacteria, fungi, viruses). Bacterial Sensitivity Tests,Drug Sensitivity Assay, Microbial,Minimum Inhibitory Concentration,Antibacterial Susceptibility Breakpoint Determination,Antibiogram,Antimicrobial Susceptibility Breakpoint Determination,Bacterial Sensitivity Test,Breakpoint Determination, Antibacterial Susceptibility,Breakpoint Determination, Antimicrobial Susceptibility,Fungal Drug Sensitivity Tests,Fungus Drug Sensitivity Tests,Sensitivity Test, Bacterial,Sensitivity Tests, Bacterial,Test, Bacterial Sensitivity,Tests, Bacterial Sensitivity,Viral Drug Sensitivity Tests,Virus Drug Sensitivity Tests,Antibiograms,Concentration, Minimum Inhibitory,Concentrations, Minimum Inhibitory,Inhibitory Concentration, Minimum,Inhibitory Concentrations, Minimum,Microbial Sensitivity Test,Minimum Inhibitory Concentrations,Sensitivity Test, Microbial,Sensitivity Tests, Microbial,Test, Microbial Sensitivity,Tests, Microbial Sensitivity
D009960 Oropharynx The middle portion of the pharynx that lies posterior to the mouth, inferior to the SOFT PALATE, and superior to the base of the tongue and EPIGLOTTIS. It has a digestive function as food passes from the mouth into the oropharynx before entering ESOPHAGUS. Oropharynxs
D005260 Female Females
D005714 Gambia A republic in western Africa, constituting an enclave within SENEGAL extending on both sides of the Gambia River. Its capital is Banjul, formerly Bathurst. Republic of the Gambia
D006192 Haemophilus Infections Infections with bacteria of the genus HAEMOPHILUS. Hemophilus Infections,Haemophilus influenzae Infection,Haemophilus influenzae Type b Infection,Hib Infection,Infections, Haemophilus,Infections, Hemophilus,Haemophilus Infection,Haemophilus influenzae Infections,Hemophilus Infection,Hib Infections,Infection, Haemophilus,Infection, Haemophilus influenzae,Infection, Hemophilus,Infection, Hib
D006193 Haemophilus influenzae A species of HAEMOPHILUS found on the mucous membranes of humans and a variety of animals. The species is further divided into biotypes I through VIII. Bacterium influenzae,Coccobacillus pfeifferi,Haemophilus meningitidis,Hemophilus influenzae,Influenza-bacillus,Mycobacterium influenzae
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012307 Risk Factors An aspect of personal behavior or lifestyle, environmental exposure, inborn or inherited characteristic, which, based on epidemiological evidence, is known to be associated with a health-related condition considered important to prevent. Health Correlates,Risk Factor Scores,Risk Scores,Social Risk Factors,Population at Risk,Populations at Risk,Correlates, Health,Factor, Risk,Factor, Social Risk,Factors, Social Risk,Risk Factor,Risk Factor Score,Risk Factor, Social,Risk Factors, Social,Risk Score,Score, Risk,Score, Risk Factor,Social Risk Factor

Related Publications

R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Vaccination with Haemophilus influenzae type b meningococcal protein conjugate vaccine reduces oropharyngeal carriage of Haemophilus influenzae type b among American Indian children.
July 1993, The Pediatric infectious disease journal,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Carriage of Haemophilus influenzae type b in children after widespread vaccination with conjugate Haemophilus influenzae type b vaccines.
July 1993, The Pediatric infectious disease journal,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Reduction of oropharyngeal carriage of Haemophilus influenzae type b (Hib) in children immunized with an Hib conjugate vaccine.
November 1991, The Journal of infectious diseases,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Epidemiology of invasive Haemophilus influenzae type b disease among children in Finland before vaccination with Haemophilus influenzae type b conjugate vaccine.
May 1989, The Pediatric infectious disease journal,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Vaccination with Haemophilus influenzae type b conjugate vaccine reduces bacterial meningitis in Morocco.
March 2012, Vaccine,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Impact of routine vaccination with a conjugate Haemophilus influenzae type b vaccine.
January 2004, Vaccine,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Haemophilus influenzae type b conjugate vaccine.
January 1988, Journal of pediatric health care : official publication of National Association of Pediatric Nurse Associates & Practitioners,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
The impact of conjugate vaccine on carriage of Haemophilus influenzae type b.
January 1995, The Journal of infectious diseases,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
[Vaccination of splenectomized children. Antibody response to Haemophilus influenzae type b conjugate vaccine].
January 1994, Ugeskrift for laeger,
R A Adegbola, and E K Mulholland, and O Secka, and S Jaffar, and B M Greenwood
Haemophilus influenzae infections in the H. influenzae type b conjugate vaccine era.
November 2011, Journal of clinical microbiology,
Copied contents to your clipboard!