-transparent.png){kind=logo}
It has been suggested that changes in the micro circulatory system are related to the early production of acute gastric mucosal injury and inflammatory factors such as prostaglandins, histamine, etc., have been considered as contributing to the development of the injury. We assessed the permeability of the gastric mucosa in rats with ethanol-induced acute mucosal injury by measuring the leakage rate of 51chronium-ethylene-diamine-tetraacetic acid (51Cr-EDTA) into the gastric juice. Histamine concentrations in the gastric mucosa was measured by high performance liquid chromatography. The enterochromaffin-like (ECL) cell counts in the gastric mucosa was performed following histamine staining with an enzyme-labeled antibody, and the histamine released due to degranulation was observed. We also investigated the kinetics of endogenous histamine in the gastric mucosa. Five minutes after the administration of ethanol, an increase in permeability, an increase in histamine concentration, and a decrease in ECL cell count were found in the gastric mucosa. These results suggest that endogenous histamine in the gastric mucosa is closely related to the early development of acute gastric mucosal injury.
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
October 1989,
Gastroenterologia Japonica,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
November 2020,
Molecular biology reports,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
January 1986,
Pharmacology,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
May 2024,
Molecular biology reports,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
January 1991,
Advances in prostaglandin, thromboxane, and leukotriene research,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
August 2000,
Journal of gastroenterology and hepatology,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
May 1995,
Gut,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
July 1988,
Digestive diseases and sciences,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
January 1993,
Journal of gastroenterology and hepatology,
Y Shindo, and
M Konagaya, and
S Harasawa, and
T Miwa, and
Y Osamura
August 1991,
European journal of pharmacology,
