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We recently observed a 45-year-old patient with a history of psychiatric illness who presented with severe hyperthermia (rectal temperature above 41 degrees C) with intense rhabdomyolysis and liver cytolysis during tetrabenazine therapy for neuroleptic tardive dyskinesia. In addition to tetrabenazine, this patient took lorazepam and two antidepressant drugs: clomipramine, a potent serotonin-reuptake inhibitor, and mianserin. Hyperthermia responded to parenteral sodium dantrolene and oral bromocriptine administration. The significant role of tetrabenazine (a central nervous system dopamine-depleting drug) and the contribution of antidepressants to the mechanism of this neuroleptic malignant syndrome - like hyperthermia are discussed.
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
January 2018,
Clinical schizophrenia & related psychoses,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
January 2013,
Clinical neuropharmacology,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
April 2011,
The Annals of pharmacotherapy,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
September 1980,
Postgraduate medical journal,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
August 1999,
The American journal of psychiatry,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
April 1973,
The American journal of psychiatry,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
February 1988,
Canadian journal of psychiatry. Revue canadienne de psychiatrie,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
April 2009,
Indian journal of psychiatry,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
February 2018,
Journal of comparative effectiveness research,
E Stevens, and
A Roman, and
M Houa, and
D Razavi, and
N Jaspar
August 1991,
The American journal of psychiatry,
