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Serum levels of HRP-2 antigens against Plasmodium falciparum in 568 venous blood samples collected at two general hospitals were evaluated using the ParaSight-F (Becton-Dickinson) alone (568/568 samples) or in combination (156/568 samples) with the new ICT-Malaria P.f. (ICT-diagnostic). Comparison with the reference method (thin and thick blood smears assessed by two experienced parasitologists) showed that both tests were highly sensitive (93% and 96% respectively) and specific (98% and 98% respectively). The positive predictive values of the two tests were equal (96%) and the negative predicative values were close (96% and 98% respectively). Although both tests provided results within 10 minutes and required no special equipment for interpretation, the ICT-Malaria P.f. test seemed simpler and easier to use than the ParaSight-F test. The ParaSight-F test alone was used to monitor serum antigen levels after treatment in 24 patients. Antigen levels remained positive for at least three days after disappearance of circulating parasites (range: 3 to 28 days). Evaluation of serum levels of HRP-2 antigens can be useful for emergency diagnosis, especially in patients with low circulating parasite levels. The ICT-Malaria P.f. test seems especially suited for in-field use.
J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
June 1998,
Parasite (Paris, France),
J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
May 1998,
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
January 1998,
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
January 2009,
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
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R Le Vagueresse
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J D Cavallo, and
E Hernandez, and
P Gerome, and
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J D Cavallo, and
E Hernandez, and
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N Plotton, and
T Debord, and
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
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J D Cavallo, and
E Hernandez, and
P Gerome, and
N Plotton, and
T Debord, and
R Le Vagueresse
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