[Development of synaptic contacts in the human brain during the early stages of embryogenesis]. 1976

A Z Ivanshina

The author studied the ultrastructure of forming synaptical contacts in the human brain at the early stages of development (7--8 and 9--11 week embryos). It was established that during the 7--8th week of the embryo ontogenesis the brain has already contacts of the puncta adhaerentia type and structures which by several signs can referred to transitory stages in the formation of synapses. During this period of development contacts between the axons of neuroblasts were encountered more frequently that those between the axons and bodies of nervous cells. During the 9--11th weeks of embryogenesis the human brain acquires more contacts between both the axons and the neuroblasts. At this stage there is a first appearance of synaptical structures, similar to functionally and morphologically mature synapses.

UI MeSH Term Description Entries
D001921 Brain The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM. Encephalon
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D013569 Synapses Specialized junctions at which a neuron communicates with a target cell. At classical synapses, a neuron's presynaptic terminal releases a chemical transmitter stored in synaptic vesicles which diffuses across a narrow synaptic cleft and activates receptors on the postsynaptic membrane of the target cell. The target may be a dendrite, cell body, or axon of another neuron, or a specialized region of a muscle or secretory cell. Neurons may also communicate via direct electrical coupling with ELECTRICAL SYNAPSES. Several other non-synaptic chemical or electric signal transmitting processes occur via extracellular mediated interactions. Synapse

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