BIOMAT Database Logo BIOMAT Database Logo

CXCR4 and CCR5 genetic polymorphisms in long-term nonprogressive human immunodeficiency virus infection: lack of association with mutations other than CCR5-Delta32. 1998

O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Laboratory of Immunoregulation, National Institute of Allergy and Infectious Diseases, Bethesda, Maryland 20892-1876, USA. OCohen@nih.gov

Polymorphisms in the coding sequences of CCR5 and CXCR4 were studied in a group of human immunodeficiency virus (HIV)-infected long-term nonprogressors. Two different point mutations were found in the CXCR4 coding sequence. One of these CXCR4 mutations was silent, and each was unique to two nonprogressors. The well-described 32-bp deletion within the CCR5 coding sequence (CCR5-Delta32) was found in 4 of 13 nonprogressors, and 12 different point mutations were found scattered over the CCR5 coding sequence from 8 nonprogressors. Most of the mutations created either silent or conservative changes in the predicted amino acid sequence: only one of these mutations was found in more than a single nonprogressor. All nonsilent mutations were tested in an HIV envelope-dependent fusion assay, and all functioned comparably to wild-type controls. Polymorphisms in the CXCR4 and CCR5 coding sequences other than CCR5-Delta32 do not appear to play a dominant mechanistic role in nonprogression among HIV-infected individuals.

UI MeSH Term Description Entries
D008297 Male Males
D009154 Mutation Any detectable and heritable change in the genetic material that causes a change in the GENOTYPE and which is transmitted to daughter cells and to succeeding generations. Mutations
D011110 Polymorphism, Genetic The regular and simultaneous occurrence in a single interbreeding population of two or more discontinuous genotypes. The concept includes differences in genotypes ranging in size from a single nucleotide site (POLYMORPHISM, SINGLE NUCLEOTIDE) to large nucleotide sequences visible at a chromosomal level. Gene Polymorphism,Genetic Polymorphism,Polymorphism (Genetics),Genetic Polymorphisms,Gene Polymorphisms,Polymorphism, Gene,Polymorphisms (Genetics),Polymorphisms, Gene,Polymorphisms, Genetic
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D015658 HIV Infections Includes the spectrum of human immunodeficiency virus infections that range from asymptomatic seropositivity, thru AIDS-related complex (ARC), to acquired immunodeficiency syndrome (AIDS). HTLV-III Infections,HTLV-III-LAV Infections,T-Lymphotropic Virus Type III Infections, Human,HIV Coinfection,Coinfection, HIV,Coinfections, HIV,HIV Coinfections,HIV Infection,HTLV III Infections,HTLV III LAV Infections,HTLV-III Infection,HTLV-III-LAV Infection,Infection, HIV,Infection, HTLV-III,Infection, HTLV-III-LAV,Infections, HIV,Infections, HTLV-III,Infections, HTLV-III-LAV,T Lymphotropic Virus Type III Infections, Human
D019713 Receptors, CCR5 CCR receptors with specificity for CHEMOKINE CCL3; CHEMOKINE CCL4; and CHEMOKINE CCL5. They are expressed at high levels in T-LYMPHOCYTES; B-LYMPHOCYTES; MACROPHAGES; MAST CELLS; and NK CELLS. The CCR5 receptor is used by the HUMAN IMMUNODEFICIENCY VIRUS to infect cells. Antigens, CD195,CC Chemokine Receptor 5,CCR5 Receptors,CD195 Antigens,CC-CKR5,CCR5 Receptor,CKR5 Receptors,Receptors, CKR5,Receptor, CCR5
D019718 Receptors, CXCR4 CXCR receptors with specificity for CXCL12 CHEMOKINE. The receptors may play a role in HEMATOPOIESIS regulation and can also function as coreceptors for the HUMAN IMMUNODEFICIENCY VIRUS. CXC Chemokine Receptor 4,CXCR4 Receptors,Fusin,CXCR4 Receptor,LESTR Receptor,Leukocyte-Derived Seven-Transmembrane Domain Receptor,Receptor, LESTR,Leukocyte Derived Seven Transmembrane Domain Receptor,Receptor, CXCR4

Related Publications

O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Studies in subjects with long-term nonprogressive human immunodeficiency virus infection.
January 1995, The New England journal of medicine,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Long-term nonprogressive infection with human immunodeficiency virus type 1 in a hemophilia cohort.
December 1999, The Journal of infectious diseases,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Unusual polymorphisms in human immunodeficiency virus type 1 associated with nonprogressive infection.
May 2000, Journal of virology,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Long-term nonprogressive human immunodeficiency virus-1 infection in a kidney allograft recipient.
November 1998, Transplantation,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Lack of association of human chemokine receptor gene polymorphisms CCR2-64I and CCR5-Delta32 with autoimmune Addison's disease.
April 2004, European journal of immunogenetics : official journal of the British Society for Histocompatibility and Immunogenetics,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Neutralizing antibody responses to human immunodeficiency virus type 1 in primary infection and long-term-nonprogressive infection.
October 1997, The Journal of infectious diseases,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Lack of Association Between the CCR5-delta32 Polymorphism and Neurodegenerative Disorders.
January 2020, Alzheimer disease and associated disorders,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Long-term control of HIV by CCR5 Delta32/Delta32 stem-cell transplantation.
February 2009, The New England journal of medicine,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
High frequency of defective nef alleles in a long-term survivor with nonprogressive human immunodeficiency virus type 1 infection.
November 1996, Journal of virology,
O J Cohen, and S Paolucci, and S M Bende, and M Daucher, and H Moriuchi, and M Moriuchi, and C Cicala, and R T Davey, and B Baird, and A S Fauci
Tuberculous pericarditis in a woman infected with human immunodeficiency virus type 1, long-term nonprogressive.
June 1997, Archives of internal medicine,
Copied contents to your clipboard!