-transparent.png){kind=logo}
A 28 year-old male patient developed anaphylactic shock on separate occasions, possibly due to the contact with a central venous catheter impregnated with chlorhexidine and silver sulfadiazine. He was successfully resuscitated. On the second operation, blood basophils disappeared and plasma histamine level increased extremely up to 80 ng.ml-1 soon after anaphylactic shock. One year after the first shock, he did not develop anaphylactic shock following the insertion of a central venous catheter without the impregnation. Pin prick test and scratch test showed positive reactions only to chlorhexidine. Latex-specific anti-IgE antibody was not detected. Therefore, chlorhexidine was confirmed as the causative agent of anaphylactic shock. Because chlorhexidine is extensively used as an antiseptic drug in emergency rooms and intensive care units, we should be aware of the possibility of chlorhexidine induced anaphylactic reactions.
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
March 1996,
Journal of clinical microbiology,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
October 1996,
Journal of clinical microbiology,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
March 2014,
American journal of infection control,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
October 2015,
Journal of the American College of Surgeons,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
October 2005,
Annals of internal medicine,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
December 2004,
American journal of infection control,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
April 2005,
Annals of hematology,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
December 2003,
Anaesthesia and intensive care,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
July 2015,
American journal of infection control,
E Terazawa, and
K Nagase, and
T Masue, and
Y Niwa, and
I Fukao, and
H Shimonaka, and
T Yokoi, and
N Kondoh, and
S Dohi
April 2012,
The new microbiologica,
