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The effects of diazepam on cerebral blood flow (CBF) and cerebral oxygen uptake (CMRO2) was studied using a 133xenon modification of the Kety-Schmidt (1948) technique in paralyzed, artifically ventilated rats with and without simultaneous administration of 70 per cent nitrous oxide. Diazepam was given iv in doses that induced light to heavy sedation or general anesthesia. When given with 70 per cent nitrous oxide, diazepam in sedative and anesthetic doses lowered CBF and CMRO2 to about 60 per cent of control. In the absence of nitrous oxide all doses of diazepam caused moderate (20-30 per cent) decreases in CBF, but CMRO2 remained unchanged or was only slightly lowered. It is concluded that diazepam interacts with nitrous oxide to produce a reduction in CMRO2 similar to that seen in barbiturate anesthesia, but that alone the drug produces sedation and anesthesia without a comparable decrease in CMRO2.
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
July 1986,
Anesthesia and analgesia,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
December 1990,
Anaesthesia,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
June 1981,
Anesthesiology,
C Carlsson, and
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A E Kaasik, and
B K Siesjö
September 2003,
Anesthesiology,
C Carlsson, and
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A E Kaasik, and
B K Siesjö
January 1976,
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C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
February 1978,
British journal of anaesthesia,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
October 1977,
Acta physiologica Scandinavica,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
April 1986,
Anesthesia and analgesia,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
September 1989,
British journal of anaesthesia,
C Carlsson, and
M Hgerdal, and
A E Kaasik, and
B K Siesjö
June 1951,
A.M.A. archives of neurology and psychiatry,
