Biomaterial Database

[Diagnostic value of total plasma levels of bile acids and ammonia in liver diseases in sheep]. 1998

P Henze, and E Humann, and P Röhrig, and K Bickhardt

Klinik für kleine Klauentiere und forensische Medizin, Tierärztlichen Hochschule Hannover.

For the estimation of the diagnostic value of plasma concentrations of total bile acids and ammonia in liver disease healthy controls (n = 23) as well as animals sick with different diseases were examined. The reference values for total bile acids and ammonia in the plasma of sheep range from 18-166 mumol/l and 15-64 mumol/l, respectively. While animals with chronic copper poisoning (n = 18), vitamin E/selenium deficiency (n = 15) and with diseases not affecting the liver (n = 8) did not show significant differences in concentrations of total bile acids and ammonia from those of the healthy controls, this could be proven for animals with severe hepatopathy or hepatoencephalopathy. Furthermore, some of the latter group showed increased ammonia concentrations in the liquor cerebrospinalis and multifocal vacuolation of the central nervous system. The determination of total bile acids and ammonia in the diagnosis of liver disease in sheep would also be useful. The hepatoencephalic syndrome should therefore be considered as possible differential diagnosis in animals showing neurological signs.

UI	MeSH Term	Description	Entries
D008107	Liver Diseases	Pathological processes of the LIVER.	Liver Dysfunction,Disease, Liver,Diseases, Liver,Dysfunction, Liver,Dysfunctions, Liver,Liver Disease,Liver Dysfunctions
D011041	Poisoning	A condition or physical state produced by the ingestion, injection, inhalation of or exposure to a deleterious agent.	Poisonings
D012016	Reference Values	The range or frequency distribution of a measurement in a population (of organisms, organs or things) that has not been selected for the presence of disease or abnormality.	Normal Range,Normal Values,Reference Ranges,Normal Ranges,Normal Value,Range, Normal,Range, Reference,Ranges, Normal,Ranges, Reference,Reference Range,Reference Value,Value, Normal,Value, Reference,Values, Normal,Values, Reference
D003300	Copper	A heavy metal trace element with the atomic symbol Cu, atomic number 29, and atomic weight 63.55.	Copper-63,Copper 63
D003677	Deficiency Diseases	A condition produced by dietary or metabolic deficiency. The term includes all diseases caused by an insufficient supply of essential nutrients, i.e., protein (or amino acids), vitamins, and minerals. It also includes an inadequacy of calories. (From Dorland, 27th ed; Stedman, 25th ed)	Deficiency Disease,Disease, Deficiency,Diseases, Deficiency
D000596	Amino Acids	Organic compounds that generally contain an amino (-NH2) and a carboxyl (-COOH) group. Twenty alpha-amino acids are the subunits which are polymerized to form proteins.	Amino Acid,Acid, Amino,Acids, Amino
D000818	Animals	Unicellular or multicellular, heterotrophic organisms, that have sensation and the power of voluntary movement. Under the older five kingdom paradigm, Animalia was one of the kingdoms. Under the modern three domain model, Animalia represents one of the many groups in the domain EUKARYOTA.	Animal,Metazoa,Animalia
D001647	Bile Acids and Salts	Steroid acids and salts. The primary bile acids are derived from cholesterol in the liver and usually conjugated with glycine or taurine. The secondary bile acids are further modified by bacteria in the intestine. They play an important role in the digestion and absorption of fat. They have also been used pharmacologically, especially in the treatment of gallstones.	Bile Acid,Bile Salt,Bile Salts,Bile Acids,Acid, Bile,Acids, Bile,Salt, Bile,Salts, Bile
D012643	Selenium	An element with the atomic symbol Se, atomic number 34, and atomic weight 78.97. It is an essential micronutrient for mammals and other animals but is toxic in large amounts. Selenium protects intracellular structures against oxidative damage. It is an essential component of GLUTATHIONE PEROXIDASE.	Selenium-80,Selenium 80
D012756	Sheep	Any of the ruminant mammals with curved horns in the genus Ovis, family Bovidae. They possess lachrymal grooves and interdigital glands, which are absent in GOATS.	Ovis,Sheep, Dall,Dall Sheep,Ovis dalli