BIOMAT Database Logo BIOMAT Database Logo

Amyloid beta-peptide(25-35) changes [Ca2+] in hippocampal neurons. 1998

H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Department of Pharmacology, University of Copenhagen, Denmark.

Insoluble aggregates of the amyloid beta-peptide (A beta) is a major constituent of senile plaques found in brains of Alzheimer disease (AD) patients. The detrimental effects of aggregated A beta is associated with an increased intracellular Ca2+ concentration ([Ca2+]i). We examined the effects of A beta(25-35) on [Ca2+]i and intracellular H+ concentration ([H+]i) in single hippocampal neurons by real time fluorescence imaging using the Ca(2+)- and H(+)-specific ratio dyes, indo-1 and SNARF-1. Incubation of these cultures with A beta(25-35) for 3-12 days in vitro increased [Ca2+]i and [H+]i in large, NMDA-responsive neurons.

UI MeSH Term Description Entries
D007211 Indoles Benzopyrroles with the nitrogen at the number one carbon adjacent to the benzyl portion, in contrast to ISOINDOLES which have the nitrogen away from the six-membered ring.
D007700 Kinetics The rate dynamics in chemical or physical systems.
D008856 Microscopy, Fluorescence Microscopy of specimens stained with fluorescent dye (usually fluorescein isothiocyanate) or of naturally fluorescent materials, which emit light when exposed to ultraviolet or blue light. Immunofluorescence microscopy utilizes antibodies that are labeled with fluorescent dye. Fluorescence Microscopy,Immunofluorescence Microscopy,Microscopy, Immunofluorescence,Fluorescence Microscopies,Immunofluorescence Microscopies,Microscopies, Fluorescence,Microscopies, Immunofluorescence
D009284 Naphthols Naphthalene derivatives carrying one or more hydroxyl (-OH) groups at any ring position. They are often used in dyes and pigments, as antioxidants for rubber, fats, and oils, as insecticides, in pharmaceuticals, and in numerous other applications. Hydroxynaphthalene,Hydroxynaphthalenes,Naphthol
D009474 Neurons The basic cellular units of nervous tissue. Each neuron consists of a body, an axon, and dendrites. Their purpose is to receive, conduct, and transmit impulses in the NERVOUS SYSTEM. Nerve Cells,Cell, Nerve,Cells, Nerve,Nerve Cell,Neuron
D010446 Peptide Fragments Partial proteins formed by partial hydrolysis of complete proteins or generated through PROTEIN ENGINEERING techniques. Peptide Fragment,Fragment, Peptide,Fragments, Peptide
D002118 Calcium A basic element found in nearly all tissues. It is a member of the alkaline earth family of metals with the atomic symbol Ca, atomic number 20, and atomic weight 40. Calcium is the most abundant mineral in the body and combines with phosphorus to form calcium phosphate in the bones and teeth. It is essential for the normal functioning of nerves and muscles and plays a role in blood coagulation (as factor IV) and in many enzymatic processes. Coagulation Factor IV,Factor IV,Blood Coagulation Factor IV,Calcium-40,Calcium 40,Factor IV, Coagulation
D002470 Cell Survival The span of viability of a cell characterized by the capacity to perform certain functions such as metabolism, growth, reproduction, some form of responsiveness, and adaptability. Cell Viability,Cell Viabilities,Survival, Cell,Viabilities, Cell,Viability, Cell
D002478 Cells, Cultured Cells propagated in vitro in special media conducive to their growth. Cultured cells are used to study developmental, morphologic, metabolic, physiologic, and genetic processes, among others. Cultured Cells,Cell, Cultured,Cultured Cell
D005456 Fluorescent Dyes Chemicals that emit light after excitation by light. The wave length of the emitted light is usually longer than that of the incident light. Fluorochromes are substances that cause fluorescence in other substances, i.e., dyes used to mark or label other compounds with fluorescent tags. Flourescent Agent,Fluorescent Dye,Fluorescent Probe,Fluorescent Probes,Fluorochrome,Fluorochromes,Fluorogenic Substrates,Fluorescence Agents,Fluorescent Agents,Fluorogenic Substrate,Agents, Fluorescence,Agents, Fluorescent,Dyes, Fluorescent,Probes, Fluorescent,Substrates, Fluorogenic

Related Publications

H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
The Ca2+ influx induced by beta-amyloid peptide 25-35 in cultured hippocampal neurons results from network excitation.
March 1995, Journal of neurobiology,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Genistein ameliorates beta-amyloid peptide (25-35)-induced hippocampal neuronal apoptosis.
January 2004, Free radical biology & medicine,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Melatonin blocks rat hippocampal neuronal apoptosis induced by amyloid beta-peptide 25-35.
April 2002, Journal of pineal research,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
[Neurotoxicity of beta-amyloid peptide 31-35 and 25-35 to cultured rat cortical neurons].
December 2009, Zhonghua yu fang yi xue za zhi [Chinese journal of preventive medicine],
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Amyloid beta peptide (25-35) inhibits Na+-dependent glutamate uptake in rat hippocampal astrocyte cultures.
July 1996, Journal of neurochemistry,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Protective effects of melatonin on cortico-hippocampal neurotoxicity induced by amyloid beta-peptide 25-35.
January 2002, Acta pharmacologica Sinica,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Differential effects of melatonin on amyloid-beta peptide 25-35-induced mitochondrial dysfunction in hippocampal neurons at different stages of culture.
March 2010, Journal of pineal research,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Beta-amyloid peptide 25-35 regulates basal and hormone-stimulated Ca2+ levels in cultured rat astrocytes.
February 1998, Neuroscience letters,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Conformations and biological activities of amyloid beta peptide 25-35.
February 2010, Current protein & peptide science,
H S Mogensen, and D M Beatty, and S J Morris, and O S Jorgensen
Amyloid beta-peptide 25-35 reduces [3H]acetylcholine release in retinal neurons. Involvement of metabolic dysfunction.
December 2002, Amyloid : the international journal of experimental and clinical investigation : the official journal of the International Society of Amyloidosis,
Copied contents to your clipboard!