Biomaterial Database

Detection of carriers of hemophilia by hemorrhagometry. 1976

C Jesdinsky-Buscher, and A H Sutor

Hemorrhagometry measures bleeding time, bleeding intensity and blood loss from a small standardized skin wound. In patients with hemophilia these values are within the normal range when hemorrhagometry is performed at room temperature (24 degrees C). However, when the wound is cooled to 17 degrees C (cold tolerance test), bleeding time is abnormally long in hemophiliacs. Therefore we applied this test to carriers of hemophilia. The cold tolerance test was performed in 16 proven and 6 probable carriers (criteria according to Nilsson). 14 proven and 4 probable carriers showed abnormal bleeding times of 15 min and more. When hemorrhagometry was performed at room temperature, the carriers could not be distinguished from normal control persons. Of 15 sisters and aunts of hemophiliacs without male offspring (potential carriers) 9 had abnormal cold tolerance test findings, in fair agreement with the probability of 0.5 to be expected theoretically. Thus the hemorrhagometry cold tolerance test seems to be helpful in detecting carriers of hemophilia.

UI	MeSH Term	Description	Entries
D008722	Methods	A series of steps taken in order to conduct research.	Techniques,Methodological Studies,Methodological Study,Procedures,Studies, Methodological,Study, Methodological,Method,Procedure,Technique
D001780	Blood Coagulation Tests	Laboratory tests for evaluating the individual's clotting mechanism.	Coagulation Tests, Blood,Tests, Blood Coagulation,Blood Coagulation Test,Coagulation Test, Blood,Test, Blood Coagulation
D003080	Cold Temperature	An absence of warmth or heat or a temperature notably below an accustomed norm.	Cold,Cold Temperatures,Temperature, Cold,Temperatures, Cold
D005260	Female		Females
D006467	Hemophilia A	The classic hemophilia resulting from a deficiency of factor VIII. It is an inherited disorder of blood coagulation characterized by a permanent tendency to hemorrhage.	Factor VIII Deficiency,Hemophilia,Autosomal Hemophilia A,Classic Hemophilia,Deficiency, Factor VIII,Factor 8 Deficiency, Congenital,Factor VIII Deficiency, Congenital,Haemophilia,Hemophilia A, Congenital,Hemophilia, Classic,As, Autosomal Hemophilia,Autosomal Hemophilia As,Classic Hemophilias,Congenital Hemophilia A,Congenital Hemophilia As,Hemophilia A, Autosomal,Hemophilia As,Hemophilia As, Autosomal,Hemophilia As, Congenital,Hemophilias, Classic
D006470	Hemorrhage	Bleeding or escape of blood from a vessel.	Bleeding,Hemorrhages
D006801	Humans	Members of the species Homo sapiens.	Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D012867	Skin	The outer covering of the body that protects it from the environment. It is composed of the DERMIS and the EPIDERMIS.
D013696	Temperature	The property of objects that determines the direction of heat flow when they are placed in direct thermal contact. The temperature is the energy of microscopic motions (vibrational and translational) of the particles of atoms.	Temperatures