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The effects of the pancreatic polypeptide amyline on ulceration and acid gastric secretion were studied in rat experiments. Pyloric ligation was used as a model of ulceration. Amyline administration caused significantly less gastric mucosal damage in response to pyloric ligation. The severity of gastric mucosal damage averaged 47 +/- 13 mm2 in the control group and 25 +/- 11 mm2 (p < 0.005). The rate of acid gastric secretion in the animals whose pylorus had been ligated as judged by the pH of gastric content was significantly higher than that in the controls (2.87 +/- 0.22 and 2.34 +/- 0.17 (p = 0.05). It is concluded that amyline has a noticeable effect on the gastric mucosa. It is suggested that suppressed acid gastric secretion, i.e. reduced influence of aggressive agents on the gastric mucosa, is a mechanism of antiulcerative action of the peptide.
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
April 1979,
The American journal of physiology,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
January 1995,
Klinicheskaia meditsina,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
March 1982,
Regulatory peptides,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
September 1979,
Life sciences,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
September 1984,
Scandinavian journal of gastroenterology,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
January 1976,
Advances in prostaglandin and thromboxane research,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
December 1978,
The American journal of digestive diseases,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
January 2004,
Journal of ethnopharmacology,
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
March 1998,
Inflammation research : official journal of the European Histamine Research Society ... [et al.],
S V German, and
G J Kuper, and
G N Kopylova, and
G E Samonina, and
G V Vorozheĭkina, and
Z V Bakaeva, and
R D Platonova
November 1995,
The American journal of physiology,
