Biomaterial Database

Glucose, lactate, and beta-hydroxybutyrate utilization by rainbow trout brain: changes during food deprivation. 1998

J L Soengas, and E F Strong, and M D Andrés

Laboratorio de Fisioloxía Animal, Facultade de Ciencias, Universidade de Vigo, Spain.

In order to evaluate the normal (fed conditions) substrate utilization rates of rainbow trout (Oncorhynchus mykiss) brain, CO2 production from glucose, lactate, and beta-hydroxybutyrate was tested in pooled brains. Oxidation rates, as well as the capacity for metabolism of carbohydrate and ketone bodies, were also evaluated in brain of rainbow trout that were food-deprived for 14 d. Under normal (fed) conditions, rainbow trout brain oxidized glucose and lactate at rates higher than those described for mammals; oxidation rates of beta-hydroxybutyrate were lower in rainbow trout brain than those observed for lactate and glucose, and also lower than those described for mammals. Under food-deprivation conditions, glucose and lactate oxidation rates decreased in brains, suggesting the existence of brain metabolic depression, and beta-hydroxybutyrate oxidation rates sharply increased, suggesting increased utilization of ketone bodies.

UI	MeSH Term	Description	Entries
D007700	Kinetics	The rate dynamics in chemical or physical systems.
D007773	Lactates	Salts or esters of LACTIC ACID containing the general formula CH3CHOHCOOR.
D010101	Oxygen Consumption	The rate at which oxygen is used by a tissue; microliters of oxygen STPD used per milligram of tissue per hour; the rate at which oxygen enters the blood from alveolar gas, equal in the steady state to the consumption of oxygen by tissue metabolism throughout the body. (Stedman, 25th ed, p346)	Consumption, Oxygen,Consumptions, Oxygen,Oxygen Consumptions
D001921	Brain	The part of CENTRAL NERVOUS SYSTEM that is contained within the skull (CRANIUM). Arising from the NEURAL TUBE, the embryonic brain is comprised of three major parts including PROSENCEPHALON (the forebrain); MESENCEPHALON (the midbrain); and RHOMBENCEPHALON (the hindbrain). The developed brain consists of CEREBRUM; CEREBELLUM; and other structures in the BRAIN STEM.	Encephalon
D002245	Carbon Dioxide	A colorless, odorless gas that can be formed by the body and is necessary for the respiration cycle of plants and animals.	Carbonic Anhydride,Anhydride, Carbonic,Dioxide, Carbon
D005508	Food Deprivation	The withholding of food in a structured experimental situation.	Deprivation, Food,Deprivations, Food,Food Deprivations
D005947	Glucose	A primary source of energy for living organisms. It is naturally occurring and is found in fruits and other parts of plants in its free state. It is used therapeutically in fluid and nutrient replacement.	Dextrose,Anhydrous Dextrose,D-Glucose,Glucose Monohydrate,Glucose, (DL)-Isomer,Glucose, (alpha-D)-Isomer,Glucose, (beta-D)-Isomer,D Glucose,Dextrose, Anhydrous,Monohydrate, Glucose
D006003	Glycogen
D006019	Glycolysis	A metabolic process that converts GLUCOSE into two molecules of PYRUVIC ACID through a series of enzymatic reactions. Energy generated by this process is conserved in two molecules of ATP. Glycolysis is the universal catabolic pathway for glucose, free glucose, or glucose derived from complex CARBOHYDRATES, such as GLYCOGEN and STARCH.	Embden-Meyerhof Pathway,Embden-Meyerhof-Parnas Pathway,Embden Meyerhof Parnas Pathway,Embden Meyerhof Pathway,Embden-Meyerhof Pathways,Pathway, Embden-Meyerhof,Pathway, Embden-Meyerhof-Parnas,Pathways, Embden-Meyerhof
D006885	Hydroxybutyrates	Salts and esters of hydroxybutyric acid.	Hydroxybutyric Acid Derivatives,Hydroxybutyric Acids,Acid Derivatives, Hydroxybutyric