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Female transgenic mice lacking a functional c-mos proto-oncogene develop ovarian teratomas, indicating that c-mos may behave as a tumour-suppressor gene for this type of tumour. We have analysed the entire coding region of the c-MOS gene in a series of human ovarian teratomas to determine whether there are any cancer-causing alterations. DNA from twenty teratomas was analysed by single-strand conformational analysis (SSCA) and heteroduplex analysis (HA) to screen for somatic and germline mutations. In nine of these tumours the entire gene was also sequenced. A previously reported polymorphism and a single new sequence variant were identified, neither of which we would predict to be disease-causing alterations. These results suggest that mutations in the coding region of the c-MOS gene do not play a significant role in the genesis of human ovarian teratomas.
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
September 1985,
The EMBO journal,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
June 1993,
Oncogene,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
January 1990,
Ciba Foundation symposium,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
March 1994,
Fertility and sterility,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
June 1995,
Japanese journal of cancer research : Gann,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
January 1985,
Nature,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
October 1986,
Biochemical and biophysical research communications,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
August 1996,
British journal of cancer,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
February 1988,
Molecular and cellular biology,
K A de Foy, and
S A Gayther, and
W H Colledge, and
S Crockett, and
I V Scott, and
M J Evans, and
B A Ponder
January 1991,
Anticancer research,
