-transparent.png){kind=logo}
Since apolipoprotein E4 (apoE4) is the major genetic risk for late onset Alzheimer's disease (AD), proteins that interact with apoE might be involved in AD pathogenesis. Low density lipoprotein receptor related protein (LRP) is an apoE receptor in the brain. In exon 3 of the LRP gene a polymorphism was found to be underrepresented in AD compared to normal Caucasian subjects (N). We examined this polymorphism in Chinese AD and N subjects. The polymorphism frequency in N was roughly half that reported for Caucasians. Compared to N, the frequency was significantly decreased in pathologically diagnosed, but not in clinically diagnosed AD patients. Thus, the role of the LRP exon 3 polymorphism in AD has now been demonstrated in two ethnic groups, suggesting the importance of LRP in AD pathogenesis.
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
January 1999,
Neuroscience letters,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
June 1998,
Neurology,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
December 2001,
Neuroscience letters,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
August 2003,
American journal of medical genetics. Part B, Neuropsychiatric genetics : the official publication of the International Society of Psychiatric Genetics,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
October 2008,
Neuroscience letters,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
August 2008,
Zhonghua yi xue yi chuan xue za zhi = Zhonghua yixue yichuanxue zazhi = Chinese journal of medical genetics,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
August 1996,
Annals of neurology,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
May 2006,
Journal of gastroenterology and hepatology,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
June 2001,
Chinese medical sciences journal = Chung-kuo i hsueh k'o hsueh tsa chih,
L Baum, and
L Chen, and
H K Ng, and
Y S Chan, and
Y T Mak, and
J Woo, and
H F Chiu, and
C P Pang
October 1997,
Archives of neurology,
