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The effects of intrathecally (i.t.) administered glibenclamide, a blocker of adenosine triphosphate-sensitive potassium ( KATP) channels, on antinociception produced by i.t. norepinephrine, morphine, or 5'-N-ethylcarboxamide adenosine, an adenosine agonist, were investigated using tail-flick assay. The results showed that: 1) i.t. norepinephrine (1 nmol), morphine (0.5 nmol) and 5'-N-ethylcarboxamide adenosine (0.5 nmol) elicited prolongation of tail-flick latency, 2) i.t. glibenclamide given in 2 different doses (5 and 10 nmol) exhibited no effects on tail-flick latency, 3) the antinociception produced by norepinephrine (1 nmol) and morphine (0.5 nmol) was blocked by glibenclamide in a dose-dependent manner, 4) glibenclamide failed to modulate the effects of 5'-N-ethylcarboxamide adenosine on tail-flick latency. These observations suggest that KATP channels may play an important role in norepinephrine- and/or morphine-induced antinociception at the spinal level.
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
July 1994,
Neuroreport,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
April 1986,
Brain research,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
June 1998,
Brain research bulletin,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
July 1997,
Brain research,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
April 2000,
Anesthesia and analgesia,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
August 2004,
The International journal of neuroscience,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
April 2002,
Sheng li xue bao : [Acta physiologica Sinica],
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
January 1993,
Psychopharmacology,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
October 2012,
The Journal of physiology,
S W Yang, and
Y M Kang, and
Y Q Guo, and
J T Qiao, and
N Dafny
February 1999,
Brain research bulletin,
