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GFRalpha-1, GFRalpha-2, and GFRalpha-3 constitute a family of structurally related, glycosyl-phosphatidylinosital-linked, cell surface proteins, two of which, GFRalpha-1 and GFRalpha-2, are components of the receptor complex for the neurotrophic factors GDNF and neurturin, respectively. By screening an embryonic chicken brain cDNA library with a GFRalpha-1 probe at low stringency, we isolated cDNAs encoding an additional member of the GFRalpha family, GFRalpha-4. The nucleotide sequence predicts a 431-amino-acid secreted protein that is more closely related to GFRalpha-1 and GFRalpha-2 than to GFRalpha-3. GFRalpha-4 mRNA is expressed in distinctive patterns in the brain and several other organs and tissues of the chicken embryo. Our findings extend the family of GFRalpha proteins and provide information about the tissues in which GFRalpha-4 may function during development.
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E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
December 1997,
The Journal of biological chemistry,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
April 2006,
Brain research bulletin,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
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August 2001,
Pediatric neurology,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
August 2008,
Trends in neurosciences,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
December 2000,
The Journal of biological chemistry,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
June 2000,
European journal of endocrinology,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
January 2001,
Italian journal of anatomy and embryology = Archivio italiano di anatomia ed embriologia,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
October 2000,
International journal of molecular medicine,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
August 2000,
American journal of physiology. Cell physiology,
J Thompson, and
E Doxakis, and
L G Piñón, and
P Strachan, and
A Buj-Bello, and
S Wyatt, and
V L Buchman, and
A M Davies
March 2021,
Molecular therapy oncolytics,
