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We investigated the mechanisms of stress-induced alterations in adrenocorticotrophin (ACTH) release. Tandem parachutists received either a placebo or the beta-adrenoceptor antagonist propranolol prior to a first time parachute jump. Blood samples were drawn 4 h before, immediately after, and 1 h after the jump. Cortisol and catecholamine concentrations displayed a significant stress-induced increase in both groups. The ACTH plasma concentrations significantly increased in the placebo and the propranolol group, with significantly more pronounced changes in the propranolol-treated subjects compared to the placebo group. These data demonstrated a stress-induced increase of ACTH plasma concentrations in humans that was enhanced by beta-blockade.
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
January 1984,
Clinical and experimental pharmacology & physiology,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
December 1988,
Journal of the autonomic nervous system,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
February 1995,
Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
January 1990,
European journal of clinical pharmacology,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
January 1990,
Postgraduate medical journal,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
September 1984,
Arquivos brasileiros de cardiologia,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
November 1980,
Kidney international,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
December 1984,
British journal of clinical pharmacology,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
January 1986,
Journal of cardiovascular pharmacology,
R Oberbeck, and
T h Schürmeyer, and
R Jacobs, and
R J Benschop, and
B Sommer, and
R E Schmidt, and
M Schedlowski
August 1985,
Journal of applied physiology (Bethesda, Md. : 1985),
