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The value of the free-to-total serum prostate-specific antigen (f/t PSA) ratio was compared with that of the total prostate specific antigen (tPSA) value for the prediction of clinical stage in patients with prostate cancer. The f/t PSA ratio was obtained from the frozen sera of 56 untreated patients with histologically proven BPH and 78 patients with prostate cancer. The clinical stage was organ-confined in 36, locally advanced in 20 and metastatic in 22 patients. Serum levels of free PSA (fPSA) and tPSA were determined using a chemiluminescent enzyme immunoassay. The f/t PSA ratio was calculated by dividing the fPSA value by the tPSA value and was compared with tPSA and fPSA in the correlation with clinical stage via the Spearman rank correlation test. Patients with prostate cancer had a significantly lower f/t PSA ratio than patients with BPH. The f/t PSA ratio did not differ between patients with clinically localized and metastatic cancer. tPSA and fPSA reflected the clinical stage and the extent of bone metastasis more accurately than the f/t PSA ratio. The extent of bone metastasis had no effect on the PSA ratio. The f/t PSA ratio had no additional value in clinical staging compared to tPSA. Our study suggests that the f/t PSA ratio does not reflect tumor load.
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
February 2000,
International journal of clinical oncology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
February 1997,
The Journal of urology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
January 1999,
International urology and nephrology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
January 2012,
Mymensingh medical journal : MMJ,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
October 2003,
Rinsho byori. The Japanese journal of clinical pathology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
February 2004,
The Journal of urology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
June 1998,
The Journal of urology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
July 2001,
The Journal of urology,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
September 2010,
Saudi medical journal,
H Maeda, and
Y Arai, and
S Ishitoya, and
K Okubo, and
Y Aoki, and
T Okada, and
S Maekawa
March 2005,
Urology,
