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Vertical transmission of HIV-1 is caused by multifactorial factors. To access the relationship of viral factors involving in perinatal transmission of HIV-1 subtype E, which is the predominant type in Thailand, plasma viral load, blood CD4+ lymphocyte level, heteroduplex mobility, and V3 sequence of the HIV-1 envelope gene were studied in 32 transmitting and 25 non-transmitting mothers. We found that HIV-1 subtype E vertical transmission was strongly associated with high maternal plasma viral RNA (> 4 x 10(4) copies/ml) and high genetic diversity of envelope gene determined by heteroduplex mobility (< 0.9). The variation of nucleotide sequences in envelope gene of subtype E vertical transmission could not determine in V3 region. Hence, plasma viral load and heteroduplex mobility can be used as prediction factors in vertical transmission of HIV-1 subtype E.
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S Foongladda, and
S Chearskul, and
N Wanaprapa, and
S Likanonskul, and
U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
August 1999,
Journal of acquired immune deficiency syndromes (1999),
R Sutthent, and
S Foongladda, and
S Chearskul, and
N Wanaprapa, and
S Likanonskul, and
U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
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S Riengrojpitak, and
S Sahapong, and
C Wasi
April 2002,
Journal of acquired immune deficiency syndromes (1999),
R Sutthent, and
S Foongladda, and
S Chearskul, and
N Wanaprapa, and
S Likanonskul, and
U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
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R Sutthent, and
S Foongladda, and
S Chearskul, and
N Wanaprapa, and
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U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
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AIDS (London, England),
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S Foongladda, and
S Chearskul, and
N Wanaprapa, and
S Likanonskul, and
U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
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C Wasi
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Journal of acquired immune deficiency syndromes (1999),
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C Wasi
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Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association,
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S Sahapong, and
C Wasi
June 2009,
Journal of acquired immune deficiency syndromes (1999),
R Sutthent, and
S Foongladda, and
S Chearskul, and
N Wanaprapa, and
S Likanonskul, and
U Kositanont, and
S Riengrojpitak, and
S Sahapong, and
C Wasi
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