-transparent.png){kind=logo}
OBJECTIVE Rejection results in destruction of the intestinal mucosa. This is the major cause of morbidity and morbility in human allografts. The aim of this study was to investigate histomorphometric changes in both the graft and recipient intestinal mucosa after experimental orthotopic small bowel transplantation. METHODS Using the pig model, 21 large-white pigs underwent: laparotomy (n = 7) (control group); orthotopic small bowel transplantation without immunosuppression (n = 7); and orthotopic small bowel transplantation with cyclosporine A (n = 7). RESULTS 1) Significant reduction of total mucosal thickness (villi plus crypt) (p < 0.05) in both the graft and recipient mucosa; 2) Attenuation of this effect by administration of cyclosporine A, which reduced the loss of mucosal thickness mainly at the expense of crypt hipertrophy. CONCLUSIONS These findings suggest that villi and crypt length measurements may be a reliable method for monitoring rejection after small bowel transplantation.
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
June 1992,
Transplantation proceedings,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
December 1990,
Transplantation proceedings,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
June 1992,
Transplantation proceedings,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
June 1993,
Hepato-gastroenterology,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
February 1995,
Transplantation proceedings,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
August 2018,
Physiological research,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
April 1994,
Transplantation,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
June 1994,
Transplantation proceedings,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
May 2001,
Nihon rinsho. Japanese journal of clinical medicine,
R Martín-Crespo, and
J Bueno, and
I Alvarez, and
E De Miguel, and
J Vázquez
September 1998,
Transplantation proceedings,
