-transparent.png){kind=logo}
Live T. cruzi trypomastigotes and amastigotes possess ecto-protein tyrosine phosphatase activity as indicated by the ability of intact cells to catalyze dephosphorylation of tyrosine phosphorylated myelin basic protein, [32P]TyrRaytide, phosphotyrosine, or the phosphotyrosine analog p-nitrophenylphosphate (p-NPP). The dephosphorylation of myelin basic protein (MBP) and p-NPP was inhibited by sodium o-vanadate, zinc chloride and NaF, while dephosphorylation of [32P]TyrRaytide was insensitive to zinc chloride but sensitive to o-vanadate and NaF. In contrast, live cells were not able to dephosphorylate serine or threonine phosphorylated peptides ([32P]Kemptide) or proteins ([32P]RCM-lysozyme and [32P]MBP).
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
November 1995,
Experimental parasitology,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
May 2004,
Parasitology research,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
September 2021,
Molecules (Basel, Switzerland),
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
September 2005,
Eukaryotic cell,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
January 2021,
Frontiers in cellular and infection microbiology,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
April 2013,
Experimental parasitology,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
November 1999,
Zeitschrift fur Naturforschung. C, Journal of biosciences,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
July 2009,
Free radical biology & medicine,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
January 1985,
Comparative biochemistry and physiology. B, Comparative biochemistry,
T Furuya, and
L Zhong, and
J R Meyer-Fernandes, and
H G Lu, and
S N Moreno, and
R Docampo
May 2011,
Biochemical and biophysical research communications,
