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The prognosis of salivary gland carcinomas is difficult to assess. Simple mucin-type carbohydrates (T and sialosyl-T antigens, Tn and sialosyl-Tn antigens) have been shown to be of value in predicting prognosis for carcinomas in other locations. We studied the prognostic significance of the expression of these structures in a retrospective study of 133 patients with salivary gland carcinomas, using immunohistochemistry and a panel of well-defined monoclonal antibodies (MAbs) on formalin-fixed paraffin-embedded tissues. Sialosyl-Tn, T and sialosyl-T antigens were not correlated with prognosis. Univariate analyses showed no overall difference in survival or locoregional control between patients with Tn-positive and patients with Tn-negative tumours, but indicated that expression of the Tn antigen was associated with early locoregional recurrences and deaths. Tn was, however, not an independent prognostic factor by multivariate regression analysis.
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
August 1993,
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M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
November 1995,
European journal of cancer. Part B, Oral oncology,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
September 1994,
The journal of histochemistry and cytochemistry : official journal of the Histochemistry Society,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
March 1993,
APMIS : acta pathologica, microbiologica, et immunologica Scandinavica,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
September 2012,
Journal of oral pathology & medicine : official publication of the International Association of Oral Pathologists and the American Academy of Oral Pathology,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
January 1992,
APMIS. Supplementum,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
December 1994,
Histopathology,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
October 1999,
Virchows Archiv : an international journal of pathology,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
October 1991,
The Journal of investigative dermatology,
M H Therkildsen, and
L J Andersen, and
M Christensen, and
H S Hansen, and
T Schiødt, and
E Dabelsteen
April 2022,
Applied immunohistochemistry & molecular morphology : AIMM,
