OBJECTIVE The authors evaluated the performance of direct magnification radiography (DIMA) with digital image processing for cerebral angiography in the rat. METHODS A microfocal x-ray unit with a focal spot of 5 microns was used for cerebral angiography in 10 rats. The animals were examined form x 4 up to x 20 magnification after injection of 0.2 mL x-ray contrast medium into the common carotid artery. RESULTS Direct magnification radiography technology provides high resolution images and enables the visualization of very small vessels with high quality. It allows the peripheral branches of the middle cerebral artery or the ophthalmic artery to be visualized. Superimposition and noise effects can be excluded with digital subtraction and image processing. CONCLUSIONS The experiments show that DIMA radiography is a suitable technique for cerebral angiography in the rat.