Biomaterial Database

Cloning and mutational analysis of the Shc-phosphotyrosine interaction/phosphotyrosine-binding domain. 1998

V Yajnik, and P Blaikie, and B Margolis

New York University School of Medicine, New York, USA.

UI	MeSH Term	Description	Entries
D010957	Plasmids	Extrachromosomal, usually CIRCULAR DNA molecules that are self-replicating and transferable from one organism to another. They are found in a variety of bacterial, archaeal, fungal, algal, and plant species. They are used in GENETIC ENGINEERING as CLONING VECTORS.	Episomes,Episome,Plasmid
D011487	Protein Conformation	The characteristic 3-dimensional shape of a protein, including the secondary, supersecondary (motifs), tertiary (domains) and quaternary structure of the peptide chain. PROTEIN STRUCTURE, QUATERNARY describes the conformation assumed by multimeric proteins (aggregates of more than one polypeptide chain).	Conformation, Protein,Conformations, Protein,Protein Conformations
D011506	Proteins	Linear POLYPEPTIDES that are synthesized on RIBOSOMES and may be further modified, crosslinked, cleaved, or assembled into complex proteins with several subunits. The specific sequence of AMINO ACIDS determines the shape the polypeptide will take, during PROTEIN FOLDING, and the function of the protein.	Gene Products, Protein,Gene Proteins,Protein,Protein Gene Products,Proteins, Gene
D003001	Cloning, Molecular	The insertion of recombinant DNA molecules from prokaryotic and/or eukaryotic sources into a replicating vehicle, such as a plasmid or virus vector, and the introduction of the resultant hybrid molecules into recipient cells without altering the viability of those cells.	Molecular Cloning
D004252	DNA Mutational Analysis	Biochemical identification of mutational changes in a nucleotide sequence.	Mutational Analysis, DNA,Analysis, DNA Mutational,Analyses, DNA Mutational,DNA Mutational Analyses,Mutational Analyses, DNA
D017354	Point Mutation	A mutation caused by the substitution of one nucleotide for another. This results in the DNA molecule having a change in a single base pair.	Mutation, Point,Mutations, Point,Point Mutations
D048868	Adaptor Proteins, Signal Transducing	A broad category of carrier proteins that play a role in SIGNAL TRANSDUCTION. They generally contain several modular domains, each of which having its own binding activity, and act by forming complexes with other intracellular-signaling molecules. Signal-transducing adaptor proteins lack enzyme activity, however their activity can be modulated by other signal-transducing enzymes	Signal Transducing Adaptor Proteins
D055765	Shc Signaling Adaptor Proteins	A family of signaling adaptor proteins that contain SRC HOMOLOGY DOMAINS. Many members of this family are involved in transmitting signals from CELL SURFACE RECEPTORS to MITOGEN-ACTIVATED PROTEIN KINASES.	Shc Adaptor Proteins,Shc Family Adapter Proteins,Adaptor Proteins, Shc
D019000	Phosphotyrosine	An amino acid that occurs in endogenous proteins. Tyrosine phosphorylation and dephosphorylation plays a role in cellular signal transduction and possibly in cell growth control and carcinogenesis.	Tyrosine-O-phosphate,Tyrosine O phosphate
D033942	Adaptor Proteins, Vesicular Transport	A class of proteins involved in the transport of molecules via TRANSPORT VESICLES. They perform functions such as binding to the cell membrane, capturing cargo molecules and promoting the assembly of CLATHRIN. The majority of adaptor proteins exist as multi-subunit complexes, however monomeric varieties have also been found.	Clathrin Adaptor,Clathrin Adaptor Protein Complex,Clathrin Assembly Protein,Clathrin Assembly Protein Complex,Clathrin Assembly Proteins,Clathrin-Associated Adaptor,Clathrin-Associated Protein,Vesicular Transport Adaptor Protein,Vesicular Transport Adaptor Protein Complex,Vesicular Transport Adaptor Proteins,Adaptor Protein Complexes, Vesicular Transport,Clathrin Adaptor Protein Complexes,Clathrin Adaptors,Clathrin Assembly Protein Complexes,Clathrin-Associated Adaptors,Clathrin-Associated Proteins,Vesicular Transport Adaptor Protein Complexes,Adaptor, Clathrin,Adaptor, Clathrin-Associated,Adaptors, Clathrin,Adaptors, Clathrin-Associated,Assembly Protein, Clathrin,Assembly Proteins, Clathrin,Clathrin Associated Adaptor,Clathrin Associated Adaptors,Clathrin Associated Protein,Clathrin Associated Proteins,Protein, Clathrin Assembly,Protein, Clathrin-Associated