BIOMAT Database Logo BIOMAT Database Logo

Cerebrospinal fluid methylmalonic acid concentrations in neurological patients with low and normal serum cobalamin concentrations. 1998

D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Department of Geriatric Medicine, University Hospital Nijmegen, The Netherlands.

OBJECTIVE To determine whether cerebrospinal fluid (CSF) methylmalonic acid (MMA) is increased in neurological patients with low serum cobalamin (Cbl, vitamin B12) concentrations as opposed to neurological patients with normal serum Cbl concentrations. METHODS We measured MMA concentrations in serum and CSF of neurological patients with low serum cobalamin concentrations, but without overt cobalamin related manifestations such as anemia or combined disease of the cord, and neurological patients with normal serum cobalamin concentrations (controls). RESULTS Serum and CSF MMA concentrations were significantly higher in patients than in controls. Serum MMA was elevated in 4 patients of whom 3 had clearly elevated CSF MMA concentrations. CONCLUSIONS Strong indications for cobalamin deficiency can be found not only in serum but also in CSF of patients with seemingly asymptomatic low serum cobalamin concentrations.

UI MeSH Term Description Entries
D008297 Male Males
D008764 Methylmalonic Acid A malonic acid derivative which is a vital intermediate in the metabolism of fat and protein. Abnormalities in methylmalonic acid metabolism lead to methylmalonic aciduria. This metabolic disease is attributed to a block in the enzymatic conversion of methylmalonyl CoA to succinyl CoA. Acid, Methylmalonic
D008875 Middle Aged An adult aged 45 - 64 years. Middle Age
D001927 Brain Diseases Pathologic conditions affecting the BRAIN, which is composed of the intracranial components of the CENTRAL NERVOUS SYSTEM. This includes (but is not limited to) the CEREBRAL CORTEX; intracranial white matter; BASAL GANGLIA; THALAMUS; HYPOTHALAMUS; BRAIN STEM; and CEREBELLUM. Intracranial Central Nervous System Disorders,Brain Disorders,CNS Disorders, Intracranial,Central Nervous System Disorders, Intracranial,Central Nervous System Intracranial Disorders,Encephalon Diseases,Encephalopathy,Intracranial CNS Disorders,Brain Disease,Brain Disorder,CNS Disorder, Intracranial,Encephalon Disease,Encephalopathies,Intracranial CNS Disorder
D005260 Female Females
D006801 Humans Members of the species Homo sapiens. Homo sapiens,Man (Taxonomy),Human,Man, Modern,Modern Man
D000328 Adult A person having attained full growth or maturity. Adults are of 19 through 44 years of age. For a person between 19 and 24 years of age, YOUNG ADULT is available. Adults
D000368 Aged A person 65 years of age or older. For a person older than 79 years, AGED, 80 AND OVER is available. Elderly
D001523 Mental Disorders Psychiatric illness or diseases manifested by breakdowns in the adaptational process expressed primarily as abnormalities of thought, feeling, and behavior producing either distress or impairment of function. Mental Illness,Psychiatric Diseases,Psychiatric Disorders,Psychiatric Illness,Behavior Disorders,Diagnosis, Psychiatric,Mental Disorders, Severe,Psychiatric Diagnosis,Illness, Mental,Mental Disorder,Mental Disorder, Severe,Mental Illnesses,Psychiatric Disease,Psychiatric Disorder,Psychiatric Illnesses,Severe Mental Disorder,Severe Mental Disorders
D014805 Vitamin B 12 A cobalt-containing coordination compound produced by intestinal micro-organisms and found also in soil and water. Higher plants do not concentrate vitamin B 12 from the soil and so are a poor source of the substance as compared with animal tissues. INTRINSIC FACTOR is important for the assimilation of vitamin B 12. Cobalamin,Cyanocobalamin,Cobalamins,Eritron,Vitamin B12,B 12, Vitamin,B12, Vitamin

Related Publications

D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Cerebrospinal fluid methylmalonic acid levels in normal subjects and patients with cobalamin deficiency.
October 1991, Neurology,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Methylmalonic acid in serum from patients with neurological symptoms consistent with cobalamin deficiency.
September 1995, European journal of neurology,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Cobalamin absorption and serum homocysteine and methylmalonic acid in elderly subjects with low serum cobalamin.
July 1993, European journal of haematology,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Association between serum cobalamin and methylmalonic acid concentrations in dogs.
March 2012, Veterinary journal (London, England : 1997),
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Serum cobalamin and methylmalonic acid concentrations in dogs with chronic gastrointestinal disease.
January 2013, American journal of veterinary research,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Serum homocysteine and methylmalonic acid concentrations in Chinese Shar-Pei dogs with cobalamin deficiency.
August 2013, Veterinary journal (London, England : 1997),
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Diagnosis of cobalamin deficiency: II. Relative sensitivities of serum cobalamin, methylmalonic acid, and total homocysteine concentrations.
June 1990, American journal of hematology,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Serum cobalamin and methylmalonic acid in Alzheimer dementia.
June 1993, Acta neurologica Scandinavica,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Zinc concentrations in the cerebrospinal fluid of normal adults and patients with neurological diseases.
August 1982, Journal of neurology, neurosurgery, and psychiatry,
D Z van Asselt, and M H Karlietis, and P J Poels, and J G de Jong, and R A Wevers, and W H Hoefnagels
Effects of oral versus parenteral cobalamin supplementation on methylmalonic acid and homocysteine concentrations in dogs with chronic enteropathies and low cobalamin concentrations.
January 2019, Veterinary journal (London, England : 1997),
Copied contents to your clipboard!