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A 55-year-old woman complained of neck pain ten years after the mastectomy. She was diagnosed as multiple bone metastases and received chemoendocrine therapy with 5'-DFUR and tamoxifen. Bone scintigram showed progressive disease, so we attempted biweekly administration of fadrozole and pamidronate (30 mg). After four months, pamidronate administration relieved her neck pain. CT revealed that all lytic lesions of cervical and thoracic vertebra showed sclerosis 11 months after pamidronate infusion. New lytic lesions are not defined, and the sclerosis has continued thus far. Pamidronate therapy is promising as an effective treatment in patients with osteolytic metastasis from breast cancer.
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