/ In modern intensive animal farming the disposal of a large amount of waste is of great concern, as, if not properly performed, it can cause the pollution of water, mainly because of the high content of nitrate and phosphate. This paper presents the results of a study intended to assess the environmental sustainability of animal waste disposal on agricultural soils in the alluvial plain of the River Chiana (Tuscany, Italy), a particularly sensitive area because of the high vulnerability of the shallow aquifer and of the intensive agricultural and breeding activities. With this aim, a strategy has been employed, that consists of the integrated use of a management model and GISs. The consequences on groundwater of applying animal waste to different kind of soils and crop arrangements have been simulated by means of the management model GLEAMS (Groundwater Loading Effects of Agricultural Management Systems, ver 2.01). As the huge amount of data required by such a sophisticated model does not allow applications at a scale larger than the field size, IDRISI and GRASS GIS packages have been used to divide the study area into land units, with homogeneous environmental characteristics, and then to generalize on these units the outputs of the model. The main conclusions can be synthesized as follows: The amount of animal waste produced in some of the investigated areas (i.e., municipal territory) is greater than that disposable on their own agricultural soil with no risks to the groundwater; consequently a cooperative approach among municipalities is necessary in order to plan waste disposal in a comprehensive and centralized way.KEY WORDS: Land use; Animal waste disposal; Groundwater protection; GIS, Management models