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OBJECTIVE To determine the accuracy of helical computed tomography (CT) for assessing reversible changes in bronchial size and air trapping due to airway hyperreactivity. METHODS Spirometry and helical CT were performed in 15 patients with mild asthma and six healthy control subjects before and after bronchial provocation with methacholine chloride and after reversal of provocation with albuterol. CT was performed at suspended functional residual capacity and at residual volume in two lung regions (above and below the carina). Bronchial area and lung attenuation measurements were compared. RESULTS At baseline, lung attenuation frequency distribution curves were similar between the control and asthma groups. After methacholine, control subjects showed a decrease of less than 10% in the forced expiratory volume at 1 second (FEV1) and no significant differences in lung attenuation curves. Patients with asthma showed a 20%-36% decrease in FEV1, with significant decreases in the median and lowest 10th percentile regions of the attenuation curves and in the cross-sectional area of small (< 5-mm2) airways (P < .001 for all comparisons). After albuterol, control subjects showed no change in spirometric measurements, lung attenuation, or bronchial size, whereas all such parameters returned to baseline levels in patients with asthma. CONCLUSIONS Functional helical CT can accurately demonstrate reversible airflow obstruction resulting from airway hyperreactivity.
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
September 1996,
Radiology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
September 2005,
Radiology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
June 2005,
Radiology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
January 2001,
Abdominal imaging,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
October 1996,
AJR. American journal of roentgenology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
October 1986,
Radiology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
January 2003,
Abdominal imaging,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
February 1999,
Nihon Igaku Hoshasen Gakkai zasshi. Nippon acta radiologica,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
June 1996,
Radiology,
J G Goldin, and
M F McNitt-Gray, and
S M Sorenson, and
T D Johnson, and
B Dauphinee, and
E C Kleerup, and
D P Tashkin, and
D R Aberle
February 1998,
AJR. American journal of roentgenology,
