The twenty-first century will provide exciting challenges for life and health sciences librarians that will force us to redefine our position in the world of information. This rapidly changing environment influences the profession in a variety of ways including whom we serve and through what service, how and where we practice librarianship, and even the very composition of the profession itself. We must look at the changes in society and make the appropriate reciprocal changes in how we educate future librarians, how we market the profession, and how we develop the profession as a whole. We, as life and health sciences librarians, need to meet these challenges head on in order to continue the evolution of the profession well into the twenty-first century.